Yoon Ji-Seon, Shim Jiyong, Lim Jun-Man, Park Sun Gyoo
LG Household & Health Care, Seoul, Korea.
J Cosmet Dermatol. 2021 Mar;20(3):1002-1008. doi: 10.1111/jocd.13626. Epub 2020 Aug 5.
Various sebum levels can be detected in dandruff-affected scalps. However, few studies have compared the biophysical characteristics of dandruff scalps categorized based on sebum levels.
To investigate and compare the biophysical characteristics of dandruff-affected scalps categorized based on sebum levels.
Fifty-four Korean women with dandruff and 30 healthy Korean women underwent physiological measurements, including evaluation of sebum and hydration levels, pH, and transepidermal water loss (TEWL) in the scalp. The levels of the biomarkers of interleukin-8 (IL-8) and kallikrein 5 (KLK5) and corneodesmosomes were investigated in the stratum corneum (SC) of the scalp.
Dandruff was categorized as dry (low-sebum, n = 25) or oily (high-sebum, n = 29) based on a sebum cutoff level of 97.82 μg/cm . Both dry and oily dandruff-affected scalps showed significantly decreased hydration levels and increased pH and TEWL compared with healthy subjects, with hydration levels being lower in dry dandruff-affected scalps. IL-8 expression was significantly increased in the oily dandruff-affected scalp. In addition, both dry and oily dandruff-affected scalps showed significantly increased KLK5 levels in the SC, with the levels being higher in oily dandruff-affected scalps. Altered distribution of corneodesmosomes, present on the entire surface area of the corneocytes, was notable in oily dandruff-affected scalps.
The biophysical characteristics of the two types of dandruff represent the influence of different characteristics, including hydration levels, expression of IL-8 and KLK5, and corneodesmosome distribution. Thus, strategies to reduce dandruff levels should differ according to sebum levels.
在受头皮屑影响的头皮中可检测到不同的皮脂水平。然而，很少有研究比较基于皮脂水平分类的头皮屑头皮的生物物理特征。
研究并比较基于皮脂水平分类的受头皮屑影响头皮的生物物理特征。
54名患有头皮屑的韩国女性和30名健康的韩国女性接受了生理测量，包括评估头皮的皮脂和水合水平、pH值和经表皮水分流失（TEWL）。在头皮角质层（SC）中研究白细胞介素-8（IL-8）、激肽释放酶5（KLK5）和角质桥粒的生物标志物水平。
根据皮脂临界水平97.82μg/cm将头皮屑分为干性（低皮脂，n = 25）或油性（高皮脂，n = 29）。与健康受试者相比，干性和油性受头皮屑影响的头皮均显示水合水平显著降低，pH值和TEWL升高，干性受头皮屑影响的头皮水合水平更低。油性受头皮屑影响的头皮中IL-8表达显著增加。此外，干性和油性受头皮屑影响的头皮在SC中的KLK5水平均显著升高，油性受头皮屑影响的头皮中水平更高。在油性受头皮屑影响的头皮中，角质形成细胞整个表面积上存在的角质桥粒分布改变明显。
两种类型头皮屑的生物物理特征代表了不同特征的影响，包括水合水平、IL-8和KLK5的表达以及角质桥粒分布。因此，减少头皮屑水平的策略应根据皮脂水平而有所不同。
