Statter M B, Foglia R P, Parks D E, Donahoe P K
Department of Surgery, Massachusetts General Hospital, Boston 02114.
J Urol. 1988 Jan;139(1):204-10. doi: 10.1016/s0022-5347(17)42354-8.
We evaluated the immunogenicity of the testis by transplanting adult, postnatal, and fetal rat testicular tissue into outbred adult female and male rats for 10 days. Testis grafts were evaluated morphometrically and histologically, and selectively compared to renal grafts previously reported in part. Testis grafts from days 15 to 21 of gestation, and from three, nine, 12 and 15 days after birth showed an overall increase in growth, with maintenance of architecture and minimal lymphocytic infiltrate. In contrast, only fetal renal tissue from days 15 to 17 demonstrated an increase in growth with maintenance of architecture and minimal lymphocytic infiltrate; grafts from later in gestation grew only slightly and showed progressive deterioration in architecture with an increasing lymphocytic infiltrate. Fifteen day fetal testis grafts were also implanted for longer intervals up to 45 days. The fetal testis grafts implanted for 20 and 30 days showed an increase in size with maintenance of architecture and minimal lymphocytic infiltrate. The observed fetal and postnatal testis growth in the non-immunosuppressed adult host makes compelling further studies directed at determining those factors contributing to the decreased immunogenicity of this organ.
我们通过将成年、出生后及胎鼠睾丸组织移植到远交系成年雌性和雄性大鼠体内10天，评估了睾丸的免疫原性。对睾丸移植物进行了形态计量学和组织学评估，并与之前部分报道的肾移植物进行了选择性比较。妊娠第15至21天以及出生后第3、9、12和15天的睾丸移植物总体生长增加，结构维持且淋巴细胞浸润极少。相比之下，只有妊娠第15至17天的胎儿肾组织生长增加，结构维持且淋巴细胞浸润极少；妊娠后期的移植物生长仅轻微，结构逐渐恶化且淋巴细胞浸润增加。15天龄胎儿睾丸移植物也植入更长时间，长达45天。植入20天和30天的胎儿睾丸移植物大小增加，结构维持且淋巴细胞浸润极少。在未免疫抑制的成年宿主中观察到的胎儿和出生后睾丸生长，促使我们进行进一步研究，以确定导致该器官免疫原性降低的因素。
