环状 RNA：生物发生、功能及在耐药肿瘤中的作用。

Department of Laboratory Medicine, Affiliated Hospital of Nantong University, NO.20, Xisi Road, Nantong, 226001, Jiangsu, China.

Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, NO.20, Xisi Road, Nantong, 226001, Jiangsu, China.

Mol Cancer. 2020 Aug 5;19(1):119. doi: 10.1186/s12943-020-01231-4.

Targeted treatment, which can specifically kill tumour cells without affecting normal cells, is a new approach for tumour therapy. However, tumour cells tend to acquire resistance to targeted drugs during treatment. Circular RNAs (circRNAs) are single-stranded RNA molecules with unique structures and important functions. With the development of RNA sequencing technology, circRNAs have been found to be widespread in tumour-resistant cells and to play important regulatory roles. In this review, we present the latest advances in circRNA research and summarize the various mechanisms underlying their regulation. Moreover, we review the role of circRNAs in the chemotherapeutic resistance of tumours and explore the clinical value of circRNA regulation in treating tumour resistance.

靶向治疗是一种针对肿瘤治疗的新方法，它可以特异性地杀死肿瘤细胞而不影响正常细胞。然而，肿瘤细胞在治疗过程中往往会对靶向药物产生耐药性。环状 RNA（circRNA）是一种具有独特结构和重要功能的单链 RNA 分子。随着 RNA 测序技术的发展，circRNA 已被发现广泛存在于耐药细胞中，并发挥重要的调控作用。在这篇综述中，我们介绍了 circRNA 研究的最新进展，并总结了其调控的各种机制。此外，我们还回顾了 circRNA 在肿瘤化疗耐药中的作用，并探讨了 circRNA 调控在治疗肿瘤耐药中的临床价值。