Henan Key Laboratory of Medical Tissue Regeneration, College of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, Henan, China.
School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, Henan, China.
Mol Cancer. 2020 Mar 14;19(1):58. doi: 10.1186/s12943-020-01180-y.
Circular RNAs (circRNAs), one type of non-coding RNA, were initially misinterpreted as nonfunctional products of pre-mRNA mis-splicing. Currently, circRNAs have been proven to manipulate the functions of diverse molecules, including non-coding RNAs, mRNAs, DNAs and proteins, to regulate cell activities in physiology and pathology. Accumulating evidence indicates that circRNAs play critical roles in tumor genesis, development, and sensitivity to radiation and chemotherapy. Radiotherapy and chemotherapy are two primary types of intervention for most cancers, but their therapeutic efficacies are usually retarded by intrinsic and acquired resistance. Thus, it is urgent to develop new strategies to improve therapeutic responses. To achieve this, clarification of the underlying mechanisms affecting therapeutic responses in cancer is needed. This review summarizes recent progress and mechanisms of circRNAs in cancer resistance to radiation and chemotherapy, and it discusses the limitations of available knowledge and potential future directions.
环状 RNA（circRNAs）是一种非编码 RNA，最初被误解为前体 mRNA 剪接错误的无功能产物。目前已经证实，circRNAs 可以调节多种分子的功能，包括非编码 RNA、mRNA、DNA 和蛋白质，从而调节生理和病理条件下的细胞活动。越来越多的证据表明，circRNAs 在肿瘤发生、发展以及对放化疗的敏感性中发挥着关键作用。放疗和化疗是大多数癌症的两种主要干预方式，但由于内在和获得性耐药性，其治疗效果通常会受到阻碍。因此，迫切需要开发新的策略来提高治疗反应。为了实现这一目标，需要阐明影响癌症放化疗治疗反应的潜在机制。本综述总结了 circRNAs 对癌症放化疗耐药性的最新进展和机制，并讨论了现有知识的局限性和潜在的未来方向。
