Pontifical Catholic University of Campinas, Campinas, SP, Brazil.
Faculty of Medicine, Pontifical Catholic University of Campinas, Campinas, SP, Brazil.
Epilepsy Behav. 2020 Oct;111:107326. doi: 10.1016/j.yebeh.2020.107326. Epub 2020 Jul 29.
The purpose of the study was to relate the Intrinsic Religiosity Inventory (IRI) with clinical epilepsy variables, the occurrence of depressive symptoms, and the quality of life (QoL) of 169 adult people with epilepsy (PWEs). Data were compared with those of a similar control group (CG) without psychiatric disorders, with p < 0.05.
A higher intrinsic religiosity (IR) was observed in PWEs when compared with the CG. Impairment in multiple cognitive domains was found in 41 (24.2%) cases, and a score >15 in the Neurological Disorders Depression Inventory for Epilepsy was observed in 44 (26%) cases. In PWE, a greater IR was associated with the use of more than one antiepileptic drug (AED), epileptiform activity (EA) in the left hemisphere, temporal lobe epilepsy with hippocampal sclerosis (TLE-HS), and the absence of depressive disorders. An early age of onset and the social functioning dimension of the Quality of Life in Epilepsy Inventory (QOLIE-31) were the predictive factors for a higher IR in the linear multivariate regression analysis.
The IR was significantly higher in PWE. A higher IR was related to TLE-HS, EA in the left hemisphere, later onset of epilepsy, a better performance in the semantic verbal fluency (SVF) test, and the absence of depressive disorders, suggesting a complex neurophysiological relationship involving multiple factors.
本研究旨在探讨内在宗教性量表（IRI）与癫痫临床变量、抑郁症状发生情况以及 169 例成年癫痫患者（PWE）生活质量（QoL）之间的关系。将患者组数据与无精神障碍的相似对照组（CG）进行比较，p 值＜0.05。
与 CG 相比，PWE 的内在宗教性（IR）更高。41 例（24.2%）存在多个认知域障碍，44 例（26%）存在神经障碍抑郁量表-癫痫评分＞15 分。在 PWE 中，IR 更高与使用多种抗癫痫药物（AED）、左半球痫样放电（EA）、伴海马硬化的颞叶癫痫（TLE-HS）以及无抑郁障碍有关。发病年龄较早和癫痫生活质量量表（QOLIE-31）的社会功能维度是线性多元回归分析中 IR 更高的预测因素。
PWE 的 IR 显著升高。更高的 IR 与 TLE-HS、左半球 EA、癫痫发病较晚、语义流畅性测试（SVF）表现更好以及无抑郁障碍有关，提示涉及多种因素的复杂神经生理关系。
