Heiland Emerald G, Ekblom Örjan, Tarassova Olga, Fernström Maria, English Coralie, Ekblom Maria M
The Swedish School of Sport and Health Sciences (GIH), Stockholm, Sweden.
School of Health Sciences and Priority Research Centre for Stroke and Brain Injury, University of Newcastle, Newcastle, NSW, Australia.
Front Hum Neurosci. 2020 Jul 14;14:273. doi: 10.3389/fnhum.2020.00273. eCollection 2020.
: Extended periods of sitting may have detrimental effects on brain health. However, the effects of breaking up prolonged sedentary periods with frequent, short physical activity bouts on mechanisms to improve brain health remain unclear. Therefore, this study aims to investigate the immediate effects of uninterrupted sitting and frequent, short bouts of physical activity on cerebral blood flow and cognitive function in the prefrontal cortex in middle-aged adults. : This is a protocol article to describe a randomized crossover study. We will collect data from 13 healthy adults, aged between 40 and 60 years old, with a body mass index <35 kg/m. Participants will be required to come into the laboratory on three occasions, sit for 3 h, and perform a different type of break for 3 min every 30 min at each visit in a random order, being either: (1) a social break; (2) brisk walk on a treadmill; or (3) simple resistance activities. Before and after each experimental condition, cerebral blood flow (primary outcome) will be measured using functional near-infrared spectroscopy (fNIRS), with short-separation channels, and working memory (1-, 2-, and 3-back on the computer) will be assessed. The following additional secondary outcomes will be collected: psychological factors (questionnaires); arterial stiffness; salivary cortisol levels; and blood glucose levels. : The results from this randomized crossover study will determine the effects of uninterrupted sitting and frequent, short bouts of physical activity on cerebral blood flow and cognitive performance. Publication of this study protocol emphasizes the importance of registration and publication of protocols in the field of sedentary behavior research.
长时间坐着可能会对大脑健康产生不利影响。然而，通过频繁的短时间体育活动来打破长时间久坐对改善大脑健康机制的影响仍不清楚。因此，本研究旨在调查中年成年人中持续久坐和频繁的短时间体育活动对前额叶皮质脑血流量和认知功能的即时影响。
这是一篇描述随机交叉研究的方案文章。我们将收集13名年龄在40至60岁之间、体重指数<35kg/m²的健康成年人的数据。参与者需要分三次到实验室，每次静坐3小时，并在每次访问时以随机顺序每30分钟进行一次不同类型的3分钟休息，休息方式为：(1)社交休息；(2)在跑步机上快走；或(3)简单的阻力活动。在每种实验条件前后，将使用具有短间隔通道的功能近红外光谱(fNIRS)测量脑血流量（主要结果），并评估工作记忆（在电脑上进行1-back、2-back和3-back任务）。还将收集以下额外的次要结果：心理因素（问卷调查）；动脉僵硬度；唾液皮质醇水平；以及血糖水平。
这项随机交叉研究的结果将确定持续久坐和频繁的短时间体育活动对脑血流量和认知表现的影响。本研究方案的发表强调了在久坐行为研究领域中方案注册和发表的重要性。
