Cheng Biheng, Jiang Tao, Zhang Lu, Hu Ruheng, Tian Jinhua, Jiang Yan, Huang Bo, Li Jun, Wei Min, Yang Jing, Ren Shengxiang, Wang Gaohua
Department of Obstetrics, Eastern Campus, Renmin Hospital, Wuhan University, Wuhan, China.
Department of Medical Oncology, Shanghai Pulmonary Hospital & Thoracic Cancer Institute, Tongji University School of Medicine, Shanghai, China.
Open Forum Infect Dis. 2020 Jul 11;7(8):ofaa294. doi: 10.1093/ofid/ofaa294. eCollection 2020 Aug.
Coronavirus disease 2019 (COVID-19) has become a pandemic. Despite the growing number of patients with COVID-19 infection, data on the clinical characteristics of pregnant patients are still limited.
We retrospectively included childbearing-age female patients with laboratory-confirmed COVID-19 at Renmin Hospital of Wuhan University from January 15 to February 23, 2020. Demographic, clinical, radiological, laboratory, and treatment data were reviewed. Clinical characteristics of pregnant and nonpregnant patients were compared.
One hundred eleven childbearing-age women with COVID-19 were included, including 16 patients (14.4%) with severe or critical disease. Compared with nonpregnant patients (n = 80), pregnant patients (n = 31) were less likely to have dyspnea (16.1% vs 37.5%), asthenia (3.2% vs 33.8%), and ≥3 symptoms (22.6% vs 45.0%); had a significantly higher neutrophil count (5.2 vs 2.5 ×10/L) and a higher percentage of CD3+ cells (76.7% vs 73.7%) and CD8+ cells (32.3% vs 28.4%); and had a dramatically lower percentage of lymphocytes (18.2% vs 31.8%), a lower CD4+/CD8+ ratio (1.2 vs 1.4), and a lower level of IgG (9.8 vs 11.9 g/L). Of note, pregnant patients had a significantly lower percentage of severe disease (3.2% vs 18.8%) and a substantially higher level of inflammation markers including neutrophil-to-lymphocyte ratio (4.4 vs 1.9) and systematic inflammatory index (812.8 vs 354.7) than nonpregnant patients. Seventeen live births were recorded, and all of these showed negative results of postnatal COVID-19 detection together with a normal Apgar score.
Pregnant patients with COVID-19 had a lower level of severity and an enhanced inflammatory response and cell immunity when compared with nonpregnant patients.
2019年冠状病毒病（COVID-19）已成为大流行病。尽管COVID-19感染患者数量不断增加，但关于孕妇临床特征的数据仍然有限。
我们回顾性纳入了2020年1月15日至2月23日在武汉大学人民医院实验室确诊为COVID-19的育龄期女性患者。对人口统计学、临床、放射学、实验室和治疗数据进行了审查。比较了孕妇和非孕妇的临床特征。
共纳入111例COVID-19育龄期女性，其中16例（14.4%）为重症或危重症患者。与非孕妇（n = 80）相比，孕妇（n = 31）出现呼吸困难的可能性较小（16.1%对37.5%）、乏力较少（3.2%对33.8%），且出现≥3种症状的情况较少（22.6%对45.0%）；中性粒细胞计数显著更高（5.2对2.5×10/L），CD3+细胞百分比更高（76.7%对73.7%），CD8+细胞百分比更高（32.3%对28.4%）；淋巴细胞百分比显著更低（18.2%对31.8%），CD4+/CD8+比值更低（1.2对1.4），IgG水平更低（9.8对
