Thomsen J H, Shug A L, Yap V U, Patel A K, Karras T J, DeFelice S L
Am J Cardiol. 1979 Feb;43(2):300-6. doi: 10.1016/s0002-9149(79)80019-3.
The possibility that DL-carnitine has a protective effect during myocardial ischemia was evaluated by performing two rapid coronary sinus pacing studies 15 minutes apart in 21 patients with coronary artery disease. Eleven patients received DL-carnitine (20 or 40 mg/kg) before the second pacing study. The treated group had a significant increase in mean heart rate (12.5 beats/min, P less than 0.001), pressure-rate product (1,912 units, P less than 0.01) and pacing duration (3.2 minutes, P less than 0.001) after the administration of carnitine. The treated group also had improvements in percent myocardial lactate extraction (8.8 percent increase, P less than 0.001) and left ventricular end-diastolic pressure (a decrease of 5.3 mm Hg, P less than 0.05). There was significantly less S-T segment depression during the second pacing period in both the untreated and treated groups. The results of this study suggest that in ischemic human hearts with reasonably well preserved left ventricular function, DL-carnitine may improve the tolerance for stress associated with an increase in heart rate and pressure-rate product.
通过对21例冠心病患者进行两项间隔15分钟的快速冠状窦起搏研究，评估了DL-肉碱在心肌缺血期间是否具有保护作用。11例患者在第二次起搏研究前接受了DL-肉碱（20或40mg/kg）。给药后，治疗组的平均心率显著增加（12.5次/分钟，P<0.001）、压力-心率乘积显著增加（1912单位，P<0.01）以及起搏持续时间显著增加（3.2分钟，P<0.001）。治疗组的心肌乳酸摄取百分比也有所改善（增加8.8%，P<0.001），左心室舒张末期压力降低（降低5.3mmHg，P<0.05）。在第二次起搏期间，未治疗组和治疗组的ST段压低均显著减轻。本研究结果表明，在左心室功能保存相对良好的缺血性人心脏中，DL-肉碱可能提高对与心率和压力-心率乘积增加相关的应激的耐受性。
