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胆脂瘤性鼓室成形术中的骨质闭塞:同种异体移植与自体鼓膜重建的安全性、卫生和听力结果。

The bony obliteration tympanoplasty in cholesteatoma: safety, hygiene and hearing outcome: allograft versus autograft tympanic membrane reconstruction.

机构信息

European Institute for ORL-HNS, GZA Hospitals Antwerp, Oosterveldlaan 24, 2610, Wilrijk, Belgium.

出版信息

Eur Arch Otorhinolaryngol. 2021 Jun;278(6):1805-1813. doi: 10.1007/s00405-020-06258-3. Epub 2020 Aug 5.

DOI:10.1007/s00405-020-06258-3
PMID:32761272
Abstract

OBJECTIVE

To evaluate early results on hygiene, safety and functional outcome in a population undergoing a canal wall up technique with bony obliteration of the mastoid and epitympanic space (CWU-BOT) for extensive cholesteatoma, performed by a single surgeon. This study compares different techniques of tympanic membrane reconstruction, viz. allografts and autografts.

PATIENTS

A consecutive series of 61 ears with acquired cholesteatoma treated with primary or revision CWU-BOT surgery from 2009 to 2014.

INTERVENTION

Obliteration was performed by the use of cortical bone-chips and bone pâté. Patients were followed up with micro-otoscopy and MRI with diffusion-weighted imaging. Ossicular reconstruction was performed using a remodelled autologous or allogenic incus or malleus.

MAIN OUTCOME MEASURES

Residual and recurrence rate and short- and mid-term hearing outcome prior to any revision tympanoplasty were analysed, the effect of type of tympanic membrane reconstruction was considered.

RESULTS

44 Ears were primary cholesteatoma cases, 17 cases were referred for revision surgery. Mean postoperative follow up was 45 months (SD 18.08) and mean follow-up until the last non-EP DW MRI 42 months (SD 17.72). Recurrent disease was present in 3%, no residual disease was present. An AC gain was seen in 75% of all ears undergoing ossicular reconstruction.

CONCLUSION

Reproducible safety, hygiene and hearing results with limited recurrence and residual disease can be obtained by younger otologic surgeons performing the BOT-CWU for extensive cholesteatoma while using a variety of grafts for tympano-ossicular reconstruction. The tympano-ossicular allograft nevertheless shows superior hearing results when a mobile intact stapes is present.

LEVEL OF EVIDENCE

Level 4.

摘要

目的

评估由同一位外科医生实施的鼓室壁完整技术(CWU-BOT)伴乳突和鼓窦区骨性填塞治疗广泛胆脂瘤的患者的早期卫生、安全性和功能结果,该技术用于治疗广泛胆脂瘤。本研究比较了不同鼓膜重建技术,即同种异体移植物和自体移植物。

患者

2009 年至 2014 年,我们连续对 61 例获得性胆脂瘤患者进行了原发性或翻修 CWU-BOT 手术。

干预措施

使用皮质骨屑和骨泥进行填塞。患者接受了显微镜耳镜检查和 MRI 检查,包括弥散加权成像。采用修整后的自体或同种异体砧骨或锤骨进行听骨重建。

主要观察指标

分析了所有鼓膜重建前的残留和复发率以及短期和中期听力结果,考虑了鼓膜重建类型的影响。

结果

44 例为原发性胆脂瘤,17 例为翻修手术。平均术后随访时间为 45 个月(SD 18.08),最后一次非 EP-DW MRI 随访时间为 42 个月(SD 17.72)。复发率为 3%,无残留病变。接受听骨重建的所有耳中有 75%的骨气导差获得了改善。

结论

年轻的耳科医生实施 CWU-BOT 治疗广泛胆脂瘤,使用各种移植物进行鼓室-听骨重建,可以获得可重复的安全性、卫生状况和听力结果,复发和残留病变的风险有限。当存在活动完整的镫骨时,听骨同种异体移植物显示出更好的听力结果。

证据水平

4 级。

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Single-shot, turbo spin-echo, diffusion-weighted imaging versus spin-echo-planar, diffusion-weighted imaging in the detection of acquired middle ear cholesteatoma.单次激发快速自旋回波扩散加权成像与自旋回波平面扩散加权成像在后天性中耳胆脂瘤检测中的比较
AJNR Am J Neuroradiol. 2006 Aug;27(7):1480-2.
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The cholesteatomatous ear one year after surgery with obliteration technique.
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S53P4生物活性玻璃用于慢性排脓性残腔二期闭塞的疗效
OTO Open. 2023 Nov 29;7(4):e96. doi: 10.1002/oto2.96. eCollection 2023 Oct-Dec.
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A retrospective analysis of hearing after cholesteatoma surgery: the bony obliteration tympanoplasty versus canal wall up and canal wall down without mastoid obliteration.胆脂瘤手术后听力的回顾性分析:骨闭塞鼓室成形术与不乳突闭塞的完壁式和开放式乳突切开术。
Eur Arch Otorhinolaryngol. 2022 Nov;279(11):5181-5189. doi: 10.1007/s00405-022-07367-x. Epub 2022 Apr 10.