College of Veterinary Medicine, Jilin University, Changchun, China.
Anat Histol Embryol. 2021 Jan;50(1):13-14. doi: 10.1111/ahe.12601. Epub 2020 Aug 5.
Identification of the specific biomarkers is of great importance to enrich and expand the gonocytes or spermatogonial stem cells (SSCs) in livestock. The glial cell line-derived neurotrophic factor (GDNF) family receptor alpha-1 (GFRα-1) is a conserved marker of the gonocytes/SSCs in multiple species including rodents, primates and human; however, its expression in bovine gonocytes/SSCs is debated. Recently, we and other teams clearly demonstrated the expression of GFRα-1 in bovine gonocytes/SSCs. This is useful for bovine gonocytes/SSCs-related research or application. Nonetheless, new methods still need to be developed to identify the undifferentiated spermatogonial subsets in large livestock and elucidate their spermatogenic potency.
鉴定特定的生物标志物对于丰富和扩展家畜中的精原细胞或精原干细胞（SSCs）非常重要。胶质细胞系衍生的神经营养因子（GDNF）家族受体α-1（GFRα-1）是多种物种（包括啮齿动物、灵长类动物和人类）中精原细胞/SSCs 的保守标志物；然而，其在牛精原细胞/SSCs 中的表达存在争议。最近，我们和其他团队明确证明了 GFRα-1 在牛精原细胞/SSCs 中的表达。这对于牛精原细胞/SSCs 相关的研究或应用很有帮助。尽管如此，仍需要开发新的方法来鉴定大型家畜中未分化的精原细胞亚群，并阐明它们的生精能力。
