Rühl U
Strahlentherapie. 1977 May;153(5):299-303.
On the bases of previous experiences and present results it can be stated that total-body irradiation is an effective therapeutical technique for treatment of lymphocytic non-Hodkin's lymphomas including chronic lymphatic leukemia; first results from prospectively randomized studies even revealed a slight superiority of this method as compared to the scheme of combined cytostatical therapy (CVP) mostly applied at present. Particular advantages of total-body irradiation are the easy applicability, the relatively short time needed for treatment, and the lack of subjective secondary effects. Thus, ambulatory therapy can be performed without any difficulty. The only complication which may occur arises from myelotoxicity reaching its maximum not earlier than after the end of treatment. Careful follow-up of the patients, therefore, is indispensable. The indication of total-body irradiation for the treatment of non-Hodgkin's lymphomas depends on the objective findings, the stage of disease, and mainly on the histological classification.
基于以往经验和目前的结果，可以说全身照射是治疗淋巴细胞性非霍奇金淋巴瘤（包括慢性淋巴细胞白血病）的一种有效治疗技术；前瞻性随机研究的初步结果甚至显示，与目前最常用的联合细胞抑制疗法（CVP）方案相比，该方法具有轻微优势。全身照射的特别优点是易于应用、治疗所需时间相对较短以及缺乏主观副作用。因此，门诊治疗可以毫无困难地进行。唯一可能出现的并发症是骨髓毒性，其在治疗结束后才达到最大值。因此，对患者进行仔细的随访是必不可少的。全身照射治疗非霍奇金淋巴瘤的适应症取决于客观检查结果、疾病分期，主要还取决于组织学分类。
