Hortegal Elane Viana Furtado, Alves Janete Janete Daniel Alencar, Santos Elton Jonh Freitas, Nunes Liliane Carvalho Rodrigues, Galvão Jacqueline Carvalho, Nunes Rafael Ferreira, Lula Dejane de Almeida, Carvalho Suena Cristina Rodrigues de, França Ana Karina Teixeira da Cunha, Santos Elisângela Milhomem Dos, Santos Alcione Miranda Dos
Department of Physiological Sciences. Federal University of Maranhão.
Postgraduate Program in Health Science. Universidade Federal do Maranhão.
Nutr Hosp. 2020 Aug 27;37(4):855-862. doi: 10.20960/nh.03068.
Introduction: in individuals with chronic kidney disease, sarcopenia is prevalent and is associated with increased morbidity and mortality, and the occurrence of cardiovascular complications. Objective: to verify the relationship between sarcopenia and inflammation in hemodialysis patients. Methods: a cross-sectional study with 209 patients in five hemodialysis units. Demographic, socioeconomic, body composition, clinical laboratory, and functional data were collected. Sarcopenia was diagnosed according to the European Working Group on Sarcopenia in Older People (grip strength < 27 kg for men and < 16 kg for women; DEXA muscle mass < 7.0 kg/m² for men and < 5.5 kg/m² for women). Inflammation was assessed by C-reactive protein. Results: mean age was 51.9 ± 15.0 years, with a predominance of males (59.3 %). The prevalence of sarcopenia was 29.1 % and that of inflammation was 50.2 %. A Poisson regression analysis showed that sarcopenia was associated with increased hsCRP values (PR: 1.06; 95 % CI: 1.01-1.10; p-value = 0.005); BMI (PR: 0.74; 95 % CI: 0.65-0.84; p-value < 0.001); age (PR: 1.02; 95 % CI: 1.00-1.03; p < 0.001); male (PR: 5.75; 95 % CI: 3.20-10.34; p-value < 0.001); presence of diabetes mellitus (DM) (PR: 1.87; 95 % CI: 1.27-2.74; p-value < 0.001); % body fat (PR: 1.07; 95 % CI: 1.04-1.09; p-value < 0.001). Conclusion: the prevalence of sarcopenia can be considered high in this study, as well as inflammation. Being inflamed, presence of DM, being male, increasing age, and % body fat were risk factors for sarcopenia. On the other hand, increased BMI had a protective role.
在慢性肾脏病患者中，肌肉减少症很常见，且与发病率和死亡率增加以及心血管并发症的发生有关。目的：验证血液透析患者中肌肉减少症与炎症之间的关系。方法：对五个血液透析单位的209名患者进行横断面研究。收集人口统计学、社会经济、身体成分、临床实验室和功能数据。根据欧洲老年人肌肉减少症工作组的标准诊断肌肉减少症（男性握力<27千克，女性握力<16千克；双能X线吸收法测定的肌肉量男性<7.0千克/平方米，女性<5.5千克/平方米）。通过C反应蛋白评估炎症。结果：平均年龄为51.9±15.0岁，男性占多数（59.3%）。肌肉减少症的患病率为29.1%，炎症的患病率为50.2%。泊松回归分析显示，肌肉减少症与高敏C反应蛋白值升高相关（PR：1.06；95%置信区间：1.01-1.10；p值=0.005）；体重指数（PR：0.74；95%置信区间：0.65-0.84；p值<0.001）；年龄（PR：1.02；95%置信区间：1.00-1.03；p<0.001）；男性（PR：5.75；95%置信区间：3.20-10.34；p值<0.001）；糖尿病（DM）的存在（PR：1.87；95%置信区间：1.27-2.74；p值<0.001）；体脂百分比（PR：1.07；95%置信区间：1.04-1.09；p值<0.001）。结论：在本研究中，肌肉减少症以及炎症的患病率都可被认为较高。炎症、糖尿病的存在、男性、年龄增长和体脂百分比是肌肉减少症的危险因素。另一方面，体重指数增加具有保护作用。
