Gross J B, Alexander C M
Department of Anesthesia, University of Pennsylvania, Philadelphia.
Anesth Analg. 1988 Jan;67(1):27-30.
A randomized, double-blind study was performed to determine how morphine 0.1 mg/kg IV, or placebo administered 80 +/- 11 (means +/- SE) minutes before the end of surgery affect recovery from isoflurane/oxygen anesthesia. End-tidal isoflurane remained constant at 1.10 +/- 0.02% (means +/- SE) in both groups intraoperatively, and no other anesthetics were given after the administration of the morphine or placebo. Duration of anesthesia did not differ significantly between the morphine (172 +/- 7 minutes) and placebo (163 +/- 18 minutes) groups. Times from discontinuation of isoflurane until eye-opening in response to verbal command were similar in the morphine (19 +/- 2 minutes) and placebo (22 +/- 3 minutes) groups. At the time of eye-opening, end-tidal isoflurane concentrations did not differ between subjects receiving morphine (0.20 +/- 0.02%) and placebo (0.18 +/- 0.01%). It is concluded that the awakening concentration (MAC-awake) during recovery from isoflurane anesthesia is approximately 0.19% and is not affected by analgesic doses or morphine.
进行了一项随机双盲研究，以确定在手术结束前80±11（均值±标准误）分钟静脉注射0.1mg/kg吗啡或安慰剂如何影响异氟烷/氧气麻醉后的恢复。术中两组患者的呼气末异氟烷浓度均维持在1.10±0.02%（均值±标准误），且在给予吗啡或安慰剂后未给予其他麻醉剂。吗啡组（172±7分钟）和安慰剂组（163±18分钟）的麻醉持续时间无显著差异。从停止使用异氟烷到对言语指令睁眼的时间在吗啡组（19±2分钟）和安慰剂组（22±3分钟）相似。睁眼时，接受吗啡的受试者（0.20±0.02%）和接受安慰剂的受试者（0.18±0.01%）的呼气末异氟烷浓度无差异。得出结论，异氟烷麻醉恢复期间的苏醒浓度（MAC-苏醒）约为0.19%，且不受镇痛剂量或吗啡的影响。
