Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114 USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Memory Research Unit, Okinawa Institute of Science and Technology Graduate University, Onna-son, Kunigami-gun, Okinawa, Japan.
Neuron. 2020 Sep 9;107(5):805-820. doi: 10.1016/j.neuron.2020.07.011. Epub 2020 Aug 6.
The hippocampus and its extended network contribute to encoding and recall of episodic experiences. Drawing from recent anatomical, physiological, and behavioral studies, we propose that hippocampal engrams function as indices to mediate memory recall. We broaden this idea to discuss potential relationships between engrams and hippocampal place cells, as well as the molecular, cellular, physiological, and circuit determinants of engrams that permit flexible routing of information to intra- and extrahippocampal circuits for reinstatement, a feature critical to memory indexing. Incorporating indexing into frameworks of memory function opens new avenues of study and even therapies for hippocampal dysfunction.
海马体及其扩展网络有助于情景体验的编码和回忆。借鉴最近的解剖学、生理学和行为学研究，我们提出海马体记忆痕迹作为介导记忆回忆的指标。我们进一步扩展这一概念，讨论记忆痕迹与海马体位置细胞之间的潜在关系，以及允许信息灵活路由到海马内外回路以进行再现的记忆痕迹的分子、细胞、生理和电路决定因素，这是记忆索引的关键特征。将索引纳入记忆功能的框架中，为海马体功能障碍的研究甚至治疗开辟了新的途径。
