Tanaka Kazumasa Z
Okinawa Institute of Science and Technology Graduate University (OIST), Japan.
Neurosci Res. 2021 Apr;165:1-5. doi: 10.1016/j.neures.2020.05.002. Epub 2020 May 20.
The hippocampus is essential for some types of memory, but its specific role remains conjectural. While studies on place cells have supported the hypothesis that the hippocampus provides a spatial substrate for episodic memory, recent engram studies have shown that optogenetic activation of a subset of hippocampal neurons that lack a temporal structure of the spike sequences can also induce memory-associated behavior. In this short review, I discuss the various lines of research that have led to different views of the role of the hippocampus in memory and propose a plausible interpretation of the findings that incorporates two influential theories.
海马体对于某些类型的记忆至关重要，但其具体作用仍存在推测性。虽然对位置细胞的研究支持了海马体为情景记忆提供空间基础的假说，但最近的印迹研究表明，对缺乏尖峰序列时间结构的海马神经元子集进行光遗传学激活也能诱导与记忆相关的行为。在这篇简短的综述中，我讨论了导致对海马体在记忆中作用产生不同观点的各种研究方向，并提出了一个结合两种有影响力理论的对这些发现的合理解释。
