Amity Institute of Molecular Medicine and Stem Cell Research (AIMMSCR), Amity University Uttar Pradesh, Noida 201313, India.
Mahavir Cancer Sansthan and Research Centre, Patna, Bihar, India.
Life Sci. 2020 Oct 15;259:118184. doi: 10.1016/j.lfs.2020.118184. Epub 2020 Aug 5.
Autophagy is an essential mechanism of cellular degradation, a way to protect the cells under stress conditions, such as deprivation of nutrients, growth factors and cellular damage. However, in normal physiology autophagy plays a significant role in cancer cells. Current research is in progress to understand how autophagy and cancer cells go hand in hand to support cancer cell progression. The important aspect in cancer and autophagy is the interdependence of autophagy in the survival and progression of cancer cells. Autophagy is known to be a major cause of chemotherapeutic resistance in various cancer cell types. Therefore, inhibition of autophagy as an effective therapeutic approach is being actively studied and tested in clinical studies. Multiple metabolic pathways are linked with autophagy that could potentially be a significant target for chemotherapeutic strategy. The comprehension of the interconnection of autophagy with cancer metabolism can pave a novel findings for effective combinatorial therapeutic strategies.
自噬是细胞降解的一种必要机制，是一种在应激条件下保护细胞的方式，例如营养物质、生长因子和细胞损伤的剥夺。然而，在正常生理条件下，自噬在癌细胞中起着重要作用。目前的研究正在进行中，以了解自噬和癌细胞是如何相互配合来支持癌细胞的进展。在癌症和自噬中重要的方面是自噬在癌细胞的存活和进展中的相互依存关系。自噬被认为是各种癌细胞类型中化疗耐药的主要原因。因此，抑制自噬作为一种有效的治疗方法正在积极的在临床研究中进行研究和测试。与自噬相关的多种代谢途径可能是化疗策略的重要靶点。对自噬与癌症代谢之间的相互联系的理解可以为有效的联合治疗策略铺平新的发现道路。
