Istituto di Genetica Molecolare CNR, Pavia, Italy.
Future Med Chem. 2013 Jun;5(9):1009-21. doi: 10.4155/fmc.13.85.
Autophagy is a catabolic process activated by stress conditions and nutrient deprivation, to which it reacts by promoting the degradation of damaged organelles and misfolded/aggregated proteins, as well as generating new energetic pools. Paradoxically, in cancer cells, which signal the dangerous microenvironment occurring during clinical therapies, autophagy could promote their proliferation and sustain drug resistance. Special attention is given to autophagy manipulation in order to counteract drug resistance of cancer cells. This article describes the basic properties of autophagy and focuses on the strategies of manipulating it.
自噬是一种由应激条件和营养缺乏激活的分解代谢过程，它通过促进受损细胞器和错误折叠/聚集蛋白质的降解，以及产生新的能量池来对此做出反应。矛盾的是，在癌细胞中，自噬可以促进它们的增殖并维持耐药性，这些细胞会发出在临床治疗过程中发生的危险微环境信号。特别关注自噬的操纵，以对抗癌细胞的耐药性。本文描述了自噬的基本特性，并重点介绍了操纵自噬的策略。
