来自乌桕的倍半木脂素和新木脂素对映体。

Sesquineolignan and neolignan enantiomers from Triadica sebifera.

作者信息

Yu Min, Zhang Yong-Li, Liu Jin-Long, Wang Su-Juan, Zhang Gui-Jie

机构信息

College of Pharmacy, Guilin Medical University, Guilin 541199, People's Republic of China.

出版信息

Bioorg Chem. 2020 Oct;103:104147. doi: 10.1016/j.bioorg.2020.104147. Epub 2020 Jul 28.

DOI:10.1016/j.bioorg.2020.104147

PMID:32763522

Abstract

Two pairs of new sesquineolignan enantiomers (1a/1b and 1c/1d), two pair of new 4',7-epoxy-8,3'-neolignan enantiomers (2a/2b and 3a/3b), and a pair of new 3',7-epoxy-8,4'-oxyneolignan enantiomers (4a/4b), along with two pairs of known 4',7-epoxy-8,3'-neolignan enantiomers (5a/5b and 6a/6b), were obtained from the stems and leaves of Triadica sebifera. The structures of the enantiomers were elucidated by spectroscopic analyses, and their absolute configurations were assigned by the experimental ECD spectra. Among them, compounds 5b, 6a and 6b showed inhibitory activities against NO production in activated microglial BV-2 cells, with IC values of 14.3, 23.2 and 33.3 μM, respectively.

摘要

从乌桕的茎和叶中获得了两对新的倍半木脂素对映体（1a/1b和1c/1d）、两对新的4',7-环氧-8,3'-新木脂素对映体（2a/2b和3a/3b）以及一对新的3',7-环氧-8,4'-氧化新木脂素对映体（4a/4b），同时还得到了两对已知的4',7-环氧-8,3'-新木脂素对映体（5a/5b和6a/6b）。通过光谱分析阐明了这些对映体的结构，并通过实验性ECD光谱确定了它们的绝对构型。其中，化合物5b、6a和6b对活化的小胶质细胞BV-2中的NO产生具有抑制活性，IC值分别为14.3、23.2和33.3 μM。