Environmental and Chemical Laboratory Services, Public Health & Environmental Laboratories, New Jersey Department of Health, Ewing, NJ, 08628, USA.
Department of Environmental Science, Rutgers University, 14 College Farm Road, New Brunswick, NJ, 08901, USA.
Chemosphere. 2020 Dec;261:127730. doi: 10.1016/j.chemosphere.2020.127730. Epub 2020 Jul 23.
The first statewide New Jersey Biomonitoring (NJBM) of serum polychlorinated biphenyls (PCBs) was conducted from 2016 to 2018. Forty ortho-substituted PCBs were measured in serum samples collected from 920 NJ residents in compliance with the CDC method. The lipid adjusted geometric mean (GM) of ∑PCB concentration for all the 920 measured subjects was 65.5 ng/g lipid (95% CIs: 56.9-75.4 ng/g lipid). Age stratified serum concentration showed that the lowest GM (33.3 ng/g lipid) was observed in the 20-39 years age group (n = 282), followed by a concentration of 76.05 ng/g lipid (n = 382) in the 40-59 years age group, and the highest GM (168.4 ng/g lipid) was found in the 60-74 years age group (n = 256). A survey regression model revealed that ∑PCBs was significantly associated with age, moderately associated with geographic region, and not significantly associated with sex. The comparison of serum PCB levels in NJBM with the sequential National Health and Nutrition Examination Survey (NHANES) data suggested that the serum PCBs in NJ adults declined 52-59% at all age groups over the last decade. Positive Matrix Factorization (PMF) suggests that ongoing and recent exposure to lower molecular weight PCBs contributes about 15% to total serum PCB levels and more in younger subjects, while higher molecular weight PCBs contribute 52% of the total serum PCB levels and more in older subjects.
2016 年至 2018 年，新泽西州进行了首次全州范围的血清多氯联苯（PCBs）生物监测（NJBM）。根据疾病预防控制中心的方法，从 920 名新泽西州居民的血清样本中测量了 40 种邻位取代的 PCBs。所有 920 名测量对象的∑PCB 浓度的脂质调整几何平均值（GM）为 65.5ng/g 脂质（95%置信区间：56.9-75.4ng/g 脂质）。按年龄分层的血清浓度显示，年龄在 20-39 岁的人群中观察到的 GM 最低（33.3ng/g 脂质）（n=282），其次是年龄在 40-59 岁的人群，浓度为 76.05ng/g 脂质（n=382），年龄在 60-74 岁的人群 GM 最高（168.4ng/g 脂质）（n=256）。调查回归模型显示，∑PCBs 与年龄显著相关，与地理区域中度相关，与性别无显著相关。NJBM 血清 PCB 水平与连续全国健康和营养检查调查（NHANES）数据的比较表明，在过去十年中，新泽西州成年人的血清 PCBs 在所有年龄段下降了 52-59%。正矩阵因子分析（PMF）表明，持续和近期接触低分子量 PCBs 对总血清 PCB 水平的贡献约为 15%，在年轻人群中更多，而高分子量 PCBs 对总血清 PCB 水平的贡献为 52%，在老年人群中更多。
