O'Hagan D T, Palin K J, Davis S S
Department of Pharmacy, University of Nottingham, England.
Crit Rev Ther Drug Carrier Syst. 1988;4(3):197-220.
Progress in the field of biotechnology has renewed interest in the oral delivery of macromolecules, in particular, proteins and peptides. While small quantities of proteins may be absorbed from the gastrointestinal tract intact, enzymatic degradation and poor absorption have historically limited protein administration to the parenteral route. By consideration of the mechanisms of macromolecular absorption from the gut, it may be possible to exploit physiological processes to promote protein uptake. However, the response of the immune system to intestinally absorbed antigen may limit the oral delivery of proteins but could provide an attractive alternative to parenteral immunization.
生物技术领域的进展重新激发了人们对大分子口服给药的兴趣，尤其是蛋白质和肽类。虽然少量蛋白质可能完整地从胃肠道吸收，但酶降解和低吸收率历来限制了蛋白质只能通过肠胃外途径给药。通过研究大分子从肠道吸收的机制，有可能利用生理过程来促进蛋白质的吸收。然而，免疫系统对肠道吸收抗原的反应可能会限制蛋白质的口服给药，但这可能为肠胃外免疫提供一种有吸引力的替代方法。
