Instituto de Microelectrónica de Sevilla, IMSE-CNM (CSIC, Universidad de Sevilla), Av. Américo Vespucio, sn, 41092 Sevilla, Spain.
Escuela Técnica Superior de Ingeniería Informática, Departamento de Tecnología Electrónica, Universidad de Sevilla, Av. Reina Mercedes sn, 41012 Sevilla, Spain.
Sensors (Basel). 2020 Aug 5;20(16):4358. doi: 10.3390/s20164358.
Porous titanium is a metallic biomaterial with good properties for the clinical repair of cortical bone tissue, although the presence of pores can compromise its mechanical behavior and clinical use. It is therefore necessary to characterize the implant pore size and distribution in a suitable way. In this work, we explore the new use of electrical impedance spectroscopy for the characterization and monitoring of titanium bone implants. Electrical impedance spectroscopy has been used as a non-invasive route to characterize the volumetric porosity percentage (30%, 40%, 50% and 60%) and the range of pore size (100-200 and 355-500 mm) of porous titanium samples obtained with the space-holder technique. Impedance spectroscopy is proved to be an appropriate technique to characterize the level of porosity of the titanium samples and pore size, in an affordable and non-invasive way. The technique could also be used in smart implants to detect changes in the service life of the material, such as the appearance of fractures, the adhesion of osteoblasts and bacteria, or the formation of bone tissue.
多孔钛是一种具有良好性能的金属生物材料，可用于临床修复皮质骨组织，尽管孔隙的存在会影响其机械性能和临床应用。因此，有必要以合适的方式对植入物的孔径和分布进行表征。在这项工作中，我们探索了电阻抗谱在钛骨植入物的表征和监测中的新用途。电阻抗谱已被用作一种非侵入性方法来表征采用空间占位技术获得的多孔钛样品的体积孔隙率（30%、40%、50%和 60%）和孔径范围（100-200 和 355-500μm）。阻抗谱被证明是一种合适的技术，可以以经济且非侵入性的方式来表征钛样品的孔隙率水平和孔径。该技术还可用于智能植入物中，以检测材料使用寿命的变化，例如出现裂缝、成骨细胞和细菌的黏附，或骨组织的形成。
