Department of Epidemiology and Prevention, Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo 162-8655, Japan.
Department of Health Administration, Furukawa Electric Corporation, Tokyo 100-8322, Japan.
Nutrients. 2020 Aug 5;12(8):2344. doi: 10.3390/nu12082344.
Calcium and phosphate may play an important role in cardio-metabolic abnormalities, including type 2 diabetes; however, epidemiological evidence of the association of calcium and phosphate status with glucose metabolism among Asians is limited. In the current study, we performed a cross-sectional analysis of the association of serum calcium, phosphate, and calcium-phosphate product concentrations with glucose metabolism markers among Japanese individuals. Overall, 1701 workers (aged 18-78 years) who participated in a health survey were enrolled in this study. Multivariable linear regression models were used to estimate means of homeostatic model assessment of insulin resistance (HOMA-IR), homeostatic model assessment of β-cell function (HOMA-β), and glycated hemoglobin (HbA1c). Serum calcium concentration was positively associated with HOMA-IR and HbA1c ( for trend < 0.01). Multivariable-adjusted means (95% confidence interval (CI)) of HOMA-IR for the lowest and highest quartiles of serum calcium were 0.78 (0.75-0.82) and 1.01 (0.96-1.07), respectively. The corresponding values for HbA1c were 5.24 (5.22-5.27) and 5.29 (5.26-5.32), respectively. Serum phosphate and calcium-phosphate product concentrations were inversely associated with HOMA-IR ( for trend 0.01). Multivariable-adjusted means (95% CI) of HOMA-IR for the lowest and highest quartiles of serum phosphate were 1.04 (0.99-1.09) and 0.72 (0.69-0.76), respectively. The corresponding values for calcium-phosphate product were 1.04 (0.99-1.09) and 0.73 (0.69-0.77), respectively. The current findings suggest that higher serum calcium and lower serum phosphate concentrations are associated with IR among apparently healthy adults.
钙和磷可能在代谢异常中发挥重要作用，包括 2 型糖尿病；然而，亚洲人群中钙和磷状态与葡萄糖代谢之间关联的流行病学证据有限。在本研究中，我们对日本人群中血清钙、磷和钙磷乘积浓度与葡萄糖代谢标志物之间的关系进行了横断面分析。共有 1701 名（年龄 18-78 岁）参加健康调查的工人被纳入本研究。采用多变量线性回归模型来估计稳态模型评估的胰岛素抵抗（HOMA-IR）、β细胞功能的稳态模型评估（HOMA-β）和糖化血红蛋白（HbA1c）的平均值。血清钙浓度与 HOMA-IR 和 HbA1c 呈正相关（趋势<0.01）。血清钙最低和最高四分位数的 HOMA-IR 多变量调整平均值（95%置信区间（CI））分别为 0.78（0.75-0.82）和 1.01（0.96-1.07）。相应的 HbA1c 值分别为 5.24（5.22-5.27）和 5.29（5.26-5.32）。血清磷和钙磷乘积浓度与 HOMA-IR 呈负相关（趋势<0.01）。血清磷最低和最高四分位数的 HOMA-IR 多变量调整平均值（95%CI）分别为 1.04（0.99-1.09）和 0.72（0.69-0.76）。相应的钙磷乘积值分别为 1.04（0.99-1.09）和 0.73（0.69-0.77）。目前的研究结果表明，在貌似健康的成年人中，较高的血清钙和较低的血清磷浓度与 IR 相关。
