Dong Hongli, Lu Nan, Wang Jie, Hu Ping
Department of Child Healthcare and Scientific Education Section, Affiliated Maternity & Child Health Care Hospital of Nantong University, Jiangsu, China.
Department of Psycho-Cardiology, Beijing Anzhen Hospital Affiliated to Capital Medical University, Beijing, China.
Asia Pac J Clin Nutr. 2025 Feb;34(1):104-111. doi: 10.6133/apjcn.202502_34(1).0010.
Mechanism studies have indicated that magnesium (Mg) and calcium (Ca) have important biological functions in glucose regulation, but epidemiological data on their associations with glycosylated hemoglobin (HbA1c) are sparse. We aimed to explore the associations of Mg and Ca with abnormal HbA1c, and examine the mediating effects of inflammation in coronary artery disease (CAD) Chinese adults.
A hospital-based cross-sectional study of 11934 patients with CAD was conducted. Serum Mg and Ca concentrations were measured.
In multivariable analyses, Mg and Mg/Ca ratio were inversely associated with abnormal HbA1c (Q4 vs Q1: ORMg: 0.61, 95% CIMg: 0.53, 0.71; ORMg/Ca ratio: 0.67, 95% CIMg/Ca ratio: 0.54, 0.84). However, null association of Ca with abnormal HbA1c was shown (Q4 vs Q1: OR: 1.15, 95% CI: 0.92, 1.44). Serum Mg and Mg/Ca ratio were inversely associated with abnormal fasting blood glucose (FBG). In contrast, serum Ca was positively associated with abnormal FBG. Path analysis indicated that there were no mediating effects of hypersensitivity C reactive protein (hsCRP) on Mg and Mg/Ca-abnormal HbA1c associations.
Our study suggested that serum Mg and Mg/Ca ratio were inversely associated with abnormal HbA1c in Chinese adults with CAD. The Mg-abnormal HbA1c relationship might not be mediated by hsCRP.
机制研究表明，镁（Mg）和钙（Ca）在血糖调节中具有重要的生物学功能，但关于它们与糖化血红蛋白（HbA1c）关联的流行病学数据较少。我们旨在探讨Mg和Ca与异常HbA1c的关联，并检验炎症在冠心病（CAD）中国成年人中的中介作用。
对11934例CAD患者进行了一项基于医院的横断面研究。测量血清Mg和Ca浓度。
在多变量分析中，Mg和Mg/Ca比值与异常HbA1c呈负相关（Q4与Q1比较：ORMg：0.61，95% CIMg：0.53，0.71；ORMg/Ca比值：0.67，95% CIMg/Ca比值：0.54，0.84）。然而，未显示Ca与异常HbA1c的关联（Q4与Q1比较：OR：1.15，95% CI：0.92，1.44）。血清Mg和Mg/Ca比值与空腹血糖异常（FBG）呈负相关。相反，血清Ca与FBG异常呈正相关。路径分析表明，超敏C反应蛋白（hsCRP）对Mg和Mg/Ca - 异常HbA1c关联无中介作用。
我们的研究表明，血清Mg和Mg/Ca比值与CAD中国成年人的异常HbA1c呈负相关。Mg与异常HbA1c的关系可能不由hsCRP介导。
