Association DESIBER, 98 rue Roger Payet, Rivière des Pluies, La Réunion, 97438 Sainte Marie, France.
CNRS, Institute of Chemistry of Natural Substances UPR2301, University of Paris-Saclay, 91198 Gif-sur-Yvette, France.
Molecules. 2020 Aug 5;25(16):3565. doi: 10.3390/molecules25163565.
With the occurrence of antibiotic-resistant strains, identification of new anti-staphylococcal drugs has become a necessity. It has long been demonstrated that plants are a large and diverse source of antibacterial compounds. , an endemic medicinal plant from Reunion Island, was chemically investigated for its reported biological activity against . Aspidin VB, a phloroglucinol derivative never before described, together with Aspidin BB, were first isolated from the ethyl acetate extract of leaves. Their structures were elucidated from spectroscopic data. Aspidin VB exhibited strong antibacterial activity against standard and methicillin-resistant strains, with a minimal inhibition concentration (MIC) of 0.25 μg/mL, and no cytotoxicity was observed at 10 M in MRC5 cells. Due to its biological activities, Aspidin VB appears to be a good natural lead in the fight against s.
随着抗生素耐药菌株的出现，寻找新的抗葡萄球菌药物已成为当务之急。长期以来，人们已经认识到植物是抗菌化合物的一个庞大而多样的来源。, 是来自留尼汪岛的一种特有药用植物，因其具有报道的抗 活性而受到研究。Aspidin VB 是一种从未被描述过的苯丙素衍生物，与 Aspidin BB 一起，首次从 叶片的乙酸乙酯提取物中分离得到。它们的结构是根据光谱数据阐明的。Aspidin VB 对标准和耐甲氧西林的 菌株表现出很强的抗菌活性，最小抑制浓度（MIC）为 0.25 μg/mL，在 MRC5 细胞中 10 μM 时没有观察到细胞毒性。由于其生物活性，Aspidin VB 似乎是对抗 s 的一个很好的天然先导化合物。
