State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China.
Department of Psychology, University of Minnesota, Minneapolis, MN, 55455, USA.
Nat Commun. 2020 Aug 6;11(1):3925. doi: 10.1038/s41467-020-17786-1.
Adaptation is a ubiquitous property of sensory systems. It is typically considered that neurons adapt to dominant energy in the ambient environment to function optimally. However, perceptual representation of the stimulus, often modulated by feedback signals, sometimes do not correspond to the input state of the stimulus, which tends to be more linked with feedforward signals. Here we investigated the relative contributions to cortical adaptation from feedforward and feedback signals, taking advantage of a visual illusion, the Flash-Grab Effect, to disassociate the feedforward and feedback representation of an adaptor. Results reveal that orientation adaptation is exclusively dependent on the perceived rather than the retinal orientation of the adaptor. Combined fMRI and EEG measurements demonstrate that the perceived orientation of the Flash-Grab Effect is indeed supported by feedback signals in the cortex. These findings highlight the important contribution of feedback signals for cortical neurons to recalibrate their sensitivity.
适应是感觉系统的普遍特性。通常认为，神经元会适应环境中的主导能量，以实现最佳功能。然而，刺激的知觉表现通常会受到反馈信号的调制，有时并不对应于刺激的输入状态，而这种状态往往与前馈信号更相关。在这里，我们利用视觉错觉“闪光抓取效应”来分离适应器的前馈和反馈表示，从而研究了前馈和反馈信号对皮层适应的相对贡献。结果表明，方向适应仅取决于适应器的感知方向，而不是视网膜方向。结合 fMRI 和 EEG 测量结果表明，在皮层中，反馈信号确实支持“闪光抓取效应”的感知方向。这些发现强调了反馈信号对皮层神经元重新校准其敏感性的重要贡献。
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