Institute of Molecular and Cellular Biology, SB RAS, Novosibirsk, Russia.
Novosibirsk State University, Novosibirsk, Russia.
Sci Rep. 2020 Aug 6;10(1):13235. doi: 10.1038/s41598-020-70226-4.
Euchromatic segments of the X chromosomes of placental mammals are the most conservative elements of the karyotype, only rarely subjected to either inter- or intrachromosomal rearrangements. Here, using microdissection-derived set of region-specific probes of Terricola savii we detailed the evolutionary rearrangements found in X chromosomes in 20 vole species (Arvicolinae, Rodentia). We show that the evolution of X chromosomes in this taxon was accompanied by multiple para- and pericentric inversions and centromere shifts. The contribution of intrachromosomal rearrangements to the karyotype evolution of Arvicolinae species was approximately equivalent in both the separate autosomal conserved segments and the X chromosomes. Intrachromosmal rearrangements and structural reorganization of the X chromosomes was likely accompanied by an accumulation, distribution, and evolution of repeated sequences.
胎盘哺乳动物 X 染色体的常染色质片段是染色体组型中最保守的元素，很少受到染色体间或染色体内重排的影响。在这里，我们使用源自 Terricola savii 的微切割衍生的一组区域特异性探针，详细描述了 20 种田鼠科物种（田鼠科，啮齿目）X 染色体中发现的进化重排。我们表明，该分类群 X 染色体的进化伴随着多个臂间和臂内倒位以及着丝粒转移。在独立的常染色体保守片段和 X 染色体中，染色体内重排对田鼠科物种的染色体组型进化的贡献大致相等。X 染色体的染色体内重排和结构重组可能伴随着重复序列的积累、分布和进化。
