奥拉帕利用于早期BRCA阳性卵巢癌的一线治疗：可行吗？可能催生一系列研究的假设。
First-Line Treatment with Olaparib for Early Stage BRCA-Positive Ovarian Cancer: May It Be Possible? Hypothesis Potentially Generating a Line of Research.
作者信息
Tomao Federica, Boccia Serena Maria, Sassu Carolina Maria, Chirra Martina, Palaia Innocenza, Petrella Maria Cristina, Di Donato Violante, Colombo Nicoletta, Benedetti Panici Pierluigi
机构信息
Department of Gynecologic Oncology, European Institute of Oncology (IEO) IRCCS, Milan, Italy.
Department of Maternal and Child Health and Urological Sciences, "Sapienza" University of Rome,Polyclinic Umberto I, Rome, Italy.
出版信息
Cancer Manag Res. 2020 Jul 7;12:5479-5489. doi: 10.2147/CMAR.S194874. eCollection 2020.
Abstract
Olaparib is currently approved in maintenance treatment of advanced ovarian cancer after response to first-line chemotherapy for breast related cancer antigens (BRCA) mutated patients. The use of this agent is based on data from SOLO1 study that observed a decreased risk of disease progression or death and a median progression-free survival about 36 months longer in case of therapy with olaparib. However, this trial recruited only patients with advanced stage ovarian cancer. The aim of this review is to retrace the available data in order to clarify the potential efficacy and feasibility of olaparib administration in newly diagnosed epithelial ovarian cancer also in early stages.
摘要
奥拉帕利目前被批准用于对一线化疗有反应的晚期卵巢癌BRCA（乳腺癌相关抗原）突变患者的维持治疗。该药物的使用基于SOLO1研究的数据，该研究观察到使用奥拉帕利治疗的患者疾病进展或死亡风险降低，无进展生存期的中位数延长约36个月。然而，该试验仅招募了晚期卵巢癌患者。本综述的目的是追溯现有数据，以阐明奥拉帕利在新诊断的早期上皮性卵巢癌中的潜在疗效和可行性。
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