Huang Ying, Zhu Meilan
Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, People's Republic of China.
Department of Rehabilitation, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, People's Republic of China.
Nat Sci Sleep. 2020 Jul 16;12:487-495. doi: 10.2147/NSS.S256625. eCollection 2020.
Although sleep problems are associated with a wide range of mental problems, it remains uncertain whether the global Pittsburgh Sleep Quality Index (PSQI) score is related to depressive symptoms in an adult population.
Data from the Midlife in the United States (MIDUS) study, including a general adult population, were obtained. A total of 1002 individuals (aged 34-84 years) were included in this study. Linear regression and logistic regression analyses were performed to investigate the association between sleep parameters from the PSQI score and depressive symptoms.
The median age of all participants was 53.0 years old, and 45.2% of them were male. After adjustments were made for sociodemographic characteristics, lifestyle factors, currently diagnosed diseases and inflammatory markers, global PSQI score was significantly associated with depression score in the linear regression model (0.298 [0.207-0.389], <0.001; Model 3). A higher global PSQI score was independently and significantly associated with depressive symptoms (score ≥16) in the logistic regression model (1.235 [1.150-1.325], <0.001; Model 3). Stratified analysis showed that the independent association between global PSQI score and depressive symptoms was affected by hypnotics use, but not antidepressants use.
A higher global PSQI score is significantly associated with a higher risk of depressive symptoms in an adult population from the United States. Future longitudinal and interventional studies are warranted to assess whether reducing the global PSQI score may improve symptoms of depression.
尽管睡眠问题与多种精神问题相关，但全球匹兹堡睡眠质量指数（PSQI）得分是否与成年人群的抑郁症状有关仍不确定。
获取了来自美国中年（MIDUS）研究的数据，该研究包括一般成年人群。本研究共纳入1002名个体（年龄34 - 84岁）。进行线性回归和逻辑回归分析，以研究PSQI得分中的睡眠参数与抑郁症状之间的关联。
所有参与者的中位年龄为53.0岁，其中45.2%为男性。在对社会人口学特征、生活方式因素、当前诊断的疾病和炎症标志物进行调整后，在线性回归模型中，全球PSQI得分与抑郁得分显著相关（0.298 [0.207 - 0.389]，<0.001；模型3）。在逻辑回归模型中，较高的全球PSQI得分与抑郁症状（得分≥16）独立且显著相关（1.235 [1.150 - 1.325]，<0.001；模型3）。分层分析表明，全球PSQI得分与抑郁症状之间的独立关联受催眠药物使用的影响，但不受抗抑郁药物使用的影响。
在美国成年人群中，较高的全球PSQI得分与较高的抑郁症状风险显著相关。未来有必要进行纵向和干预性研究，以评估降低全球PSQI得分是否可改善抑郁症状。
