Hung Hao-Chang, Lu Feng-Hwa, Ou Horng-Yih, Wu Jin-Shang, Yang Yi-Ching, Chang Chih-Jen
From the 1Division of Endocrinology and Metabolism, Department of Internal Medicine, and 2Department of Family Medicine, National Cheng Kung University Hospital, Tainan, Taiwan; and Departments of 3Family Medicine and 4Internal Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Menopause. 2014 Aug;21(8):834-9. doi: 10.1097/GME.0000000000000183.
The aim of this study was to investigate the relationship between menopause and self-reported sleep quality in Chinese women without vasomotor symptoms.
Cross-sectional data were collected from a decoded database of the National Cheng Kung University Hospital. Menopause was defined as absence of menses for at least 12 months or a history of hysterectomy and oophorectomy. Self-reported sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI). A higher global PSQI score indicates poorer self-reported sleep quality, and a global PSQI score greater than 5 differentiates poor sleepers from good sleepers.
Of the 1,088 women recruited, 353 (32.4%) were in postmenopause status. Postmenopausal women had higher mean (SD) global PSQI scores (8.0 [3.3] vs. 6.1 [2.2], P < 0.001) and a greater prevalence of poor sleepers (73.1% vs. 60.8%, P < 0.001) compared with premenopausal women. Multivariate linear regression analysis showed that menopause (β = 1.532; 95% CI, 1.135 to 1.949; P < 0.001) and snoring (β = 0.764; 95% CI, 0.299 to 1.228; P = 0.001) were positively associated with global PSQI scores, whereas long sleep duration (β = -0.791; 95% CI, -1.113 to -0.468; P < 0.001) was negatively associated with global PSQI scores. Multivariate logistic regression analyses showed that menopause (odds ratio, 1.453; 95% CI, 1.030 to 2.051; P < 0.05), long sleep duration (odds ratio, 0.545; 95% CI, 0.418 to 0.710; P < 0.001), and snoring (odds ratio, 2.022; 95% CI, 1.312 to 3.116; P = 0.001) were independent predictors of poor sleepers.
Postmenopausal women without vasomotor symptoms have significantly higher global PSQI scores and a higher risk of being poor sleepers than premenopausal women. In addition, menopause and snoring are associated with an increased risk of poor self-reported sleep quality independently of cardiometabolic factors and lifestyle, whereas long sleep duration is associated with a decreased risk of poor self-reported sleep quality.
本研究旨在调查无血管舒缩症状的中国女性绝经与自我报告的睡眠质量之间的关系。
从国立成功大学医院的一个已解码数据库中收集横断面数据。绝经定义为停经至少12个月或有子宫切除术和卵巢切除术史。使用匹兹堡睡眠质量指数（PSQI）评估自我报告的睡眠质量。PSQI全球得分越高表明自我报告的睡眠质量越差，PSQI全球得分大于5区分睡眠差者和睡眠好者。
在招募的1088名女性中，353名（32.4%）处于绝经后状态。与绝经前女性相比，绝经后女性的PSQI全球平均（标准差）得分更高（8.0[3.3]对6.1[2.2]，P<0.001），睡眠差者的患病率更高（73.1%对60.8%，P<0.001）。多变量线性回归分析显示，绝经（β=1.532；95%CI，1.135至1.949；P<0.001）和打鼾（β=0.764；95%CI，0.299至1.228；P=0.001）与PSQI全球得分呈正相关，而睡眠时间长（β=-0.791；95%CI，-1.113至-0.468；P<0.001）与PSQI全球得分呈负相关。多变量逻辑回归分析显示，绝经（比值比，1.453；95%CI，1.030至2.051；P<0.05）、睡眠时间长（比值比，0.545；95%CI，0.418至0.710；P<0.001）和打鼾（比值比，2.022；95%CI，1.312至3.116；P=0.001）是睡眠差者的独立预测因素。
无血管舒缩症状的绝经后女性比绝经前女性的PSQI全球得分显著更高，睡眠差的风险更高。此外，绝经和打鼾与自我报告的睡眠质量差的风险增加独立于心脏代谢因素和生活方式相关，而睡眠时间长与自我报告的睡眠质量差的风险降低相关。
