De Groote Evelien, De Keyser Kim, Santens Patrick, Talsma Durk, Bockstael Annelies, Botteldooren Dick, De Letter Miet
Department of Rehabilitation Sciences, Ghent University, Ghent, Belgium.
Department of Neurology, Ghent University Hospital, Ghent, Belgium.
Front Neurol. 2020 Jul 16;11:689. doi: 10.3389/fneur.2020.00689. eCollection 2020.
Research on auditory processing in Parkinson's disease (PD) has recently made substantial progress. At present, evidence has been found for altered auditory processing in the clinical stage of PD. The auditory alterations in PD have been demonstrated with low-cost and non-invasive assessments that are already used in routine clinical practice. Since auditory alterations have been reported early in disease progression, it would be highly relevant to investigate whether auditory markers could be provided in the prodromal stage of PD. In addition, auditory alterations in early stage PD might be modulated by dopaminergic medication. Therefore, the aim of this review is (1) to summarize the literature on auditory processing in PD with a specific focus on the early disease stages, (2) to give future perspectives on which audiological and electrophysiological measurements could be useful in the prodromal stage of PD and (3) to assess the effect of dopaminergic medication on potential auditory markers in the prodromal stage of PD.
帕金森病（PD）听觉处理方面的研究近来取得了重大进展。目前，已发现PD临床阶段存在听觉处理改变的证据。PD的听觉改变已通过常规临床实践中已使用的低成本、非侵入性评估得以证实。由于在疾病进展早期就已报告存在听觉改变，因此研究是否能在PD前驱期提供听觉标志物具有高度相关性。此外，早期PD的听觉改变可能受多巴胺能药物调节。因此，本综述的目的是：（1）总结关于PD听觉处理的文献，特别关注疾病早期阶段；（2）对哪些听力学和电生理测量可能对PD前驱期有用给出未来展望；（3）评估多巴胺能药物对PD前驱期潜在听觉标志物的影响。
