Aierken Aibibai, Yusufu Bweimaieryemu, Xu Peiru
Department of Pediatrics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, P.R. China.
Department of Pediatrics, First people's Hospital of Kashi, Kashi, Xinjiang 844000, P.R. China.
Exp Ther Med. 2020 Sep;20(3):2122-2126. doi: 10.3892/etm.2020.8949. Epub 2020 Jun 26.
Correlation between asthmatic infants with rickets and vitamin D, inflammatory factors and immunoglobulin was investigated. A total of 60 child patients with asthma who met the inclusion criteria and received treatment from January 2016 to October 2017 were collected. Among them, 17 asthmatic infants with rickets were set as observation group, while 43 child patients with simple asthma were regarded as the control group. Venous blood was drawn from the two groups of subjects after admission. The levels of interleukin-1 (IL-1), IL-6 and IL-17 in serum were determined by ELISA, vitamin D and immunoglobulin E levels in serum were detected using a fully-automatic biochemical analyzer, and wheezing duration during asthma attack was recorded. IL-1, IL-6, IL-17 and immunoglobulin E levels in serum of observation group were significantly higher than those of the control group (P<0.05). The vitamin D level in the observation group was remarkably lower than that in the control group (P<0.05). Wheezing duration in observation group was evidently longer than that in control group (P<0.05). Moreover, IL-1, IL-6, IL-17 and immunoglobulin E levels in serum were positively related to wheezing duration, but the vitamin D level was negatively associated with wheezing duration. Infantile asthma with rickets is closely correlated with vitamin D, inflammatory factors and immunoglobulin E, which are major risk factors in infantile asthma with rickets.
探讨哮喘合并佝偻病婴幼儿与维生素D、炎症因子及免疫球蛋白之间的相关性。收集2016年1月至2017年10月期间符合纳入标准并接受治疗的60例儿童哮喘患者。其中，17例哮喘合并佝偻病婴幼儿设为观察组，43例单纯哮喘儿童患者作为对照组。两组受试者入院后采集静脉血。采用酶联免疫吸附测定法（ELISA）测定血清白细胞介素-1（IL-1）、IL-6和IL-17水平，使用全自动生化分析仪检测血清维生素D和免疫球蛋白E水平，并记录哮喘发作时的喘息持续时间。观察组血清IL-1、IL-6、IL-17和免疫球蛋白E水平显著高于对照组（P<0.05）。观察组维生素D水平显著低于对照组（P<0.05）。观察组喘息持续时间明显长于对照组（P<0.05）。此外，血清IL-1、IL-6、IL-17和免疫球蛋白E水平与喘息持续时间呈正相关，而维生素D水平与喘息持续时间呈负相关。哮喘合并佝偻病婴幼儿与维生素D、炎症因子及免疫球蛋白E密切相关，这些是哮喘合并佝偻病婴幼儿的主要危险因素。
