a Department of Clinical & Translational Science , Creighton University School of Medicine , Omaha , NE , USA.
Expert Rev Clin Immunol. 2016 Aug;12(8):839-47. doi: 10.1586/1744666X.2016.1171143. Epub 2016 Apr 14.
Vitamin D influences allergen-induced pathways in the innate and adaptive immune system, and its potential immunomodulatory role in allergic skin disorders has been explored. This comprehensive review article provides an overview of the role of vitamin D in three common dermatologic conditions: atopic dermatitis (AD), chronic urticaria, and allergic contact dermatitis (ACD). Whereas the literature regarding vitamin D and AD has resulted in mixed findings, several studies have described an inverse relationship between vitamin D levels and AD severity, and improvement in AD with vitamin D supplementation. Similarly, several studies report an inverse relationship between vitamin D levels and severity of chronic urticaria. Although current research in humans remains limited, an increased likelihood of ACD has been demonstrated in vitamin D-deficient mice. Additional well-designed clinical trials will be necessary to determine whether vitamin D supplementation should be recommended for prevention or adjuvant treatment of these common dermatologic conditions.
维生素 D 影响先天和适应性免疫系统中的变应原诱导途径，其在过敏性皮肤疾病中的潜在免疫调节作用已被探索。这篇综述文章概述了维生素 D 在三种常见皮肤科疾病中的作用：特应性皮炎（AD）、慢性荨麻疹和过敏性接触性皮炎（ACD）。虽然关于维生素 D 与 AD 的文献得出的结果喜忧参半，但有几项研究描述了维生素 D 水平与 AD 严重程度之间的反比关系，以及维生素 D 补充对 AD 的改善。同样，有几项研究报告了维生素 D 水平与慢性荨麻疹严重程度之间的反比关系。尽管目前人类的研究仍然有限，但已证明维生素 D 缺乏的小鼠发生 ACD 的可能性增加。需要更多设计良好的临床试验来确定是否应推荐维生素 D 补充剂用于预防或辅助治疗这些常见的皮肤科疾病。
