Wei Wengong, Zhang Xiaoping
Department of Obstetrics and Gynecology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai 201700, P.R. China.
Exp Ther Med. 2020 Sep;20(3):2184-2190. doi: 10.3892/etm.2020.8952. Epub 2020 Jun 29.
Expression of adiponectin (ADP) and tumor necrosis factor-α (TNF-α) in patients with gestational diabetes mellitus and its relationship with pregnancy outcomes was explored. A total of 78 patients with gestational diabetes mellitus admitted to Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University from June 2017 to December 2018 were enrolled as an experimental group, and further 70 healthy pregnant women in physical examination during the same period were enrolled as a control group. Concentrations of ADP and TNF-α were determined and compared between the two groups. The patients were divided into high ADP expression group (≥6.84), low ADP expression group (<6.84), high TNF-α expression group (≥6.17) and low TNF-α expression group (<6.17). Corresponding two groups were compared in terms of adverse pregnancy outcomes, respectively, and they were also compared with the control group. The clinical association between ADP and TNF-α was analyzed. TNF-α was highly expressed in the blood of patients with gestational diabetes mellitus, while ADP expression was low in the blood. The low expression of ADP was related to age, pregestational body mass index (BMI), gestational week, medical history and family history of diabetes mellitus (all P<0.05), and the high expression of TNF-α was related to age, pregestational BMI, gestational week, medical history, amniotic fluid volume, abortion history, and family history of diabetes mellitus (all P<0.05). The experimental group faced a higher risk of adverse pregnancy outcomes than the control group. Both ADP and TNF-α are abnormally expressed in the patients with gestational diabetes mellitus, and TNF-α is affected by more of the factors. The concentrations of ADP and TNF-α affect the pregnancy outcomes. It suggests that ADP and TNF-α can be used as indexes for predicating pregnancy outcomes, and for judging the disease conditions and treatment of patients.
探讨妊娠糖尿病患者脂联素（ADP）和肿瘤坏死因子-α（TNF-α）的表达及其与妊娠结局的关系。选取2017年6月至2018年12月在复旦大学附属中山医院青浦分院收治的78例妊娠糖尿病患者作为实验组，另选取同期70例健康体检孕妇作为对照组。测定并比较两组患者的ADP和TNF-α浓度。将患者分为ADP高表达组（≥6.84）、ADP低表达组（<6.84）、TNF-α高表达组（≥6.17）和TNF-α低表达组（<6.17）。分别比较相应两组的不良妊娠结局，并与对照组进行比较。分析ADP与TNF-α之间的临床相关性。妊娠糖尿病患者血液中TNF-α高表达，而ADP表达低。ADP低表达与年龄、孕前体重指数（BMI）、孕周、糖尿病病史及家族史有关（均P<0.05），TNF-α高表达与年龄、孕前BMI、孕周、病史、羊水量、流产史及糖尿病家族史有关（均P<0.05）。实验组不良妊娠结局风险高于对照组。妊娠糖尿病患者中ADP和TNF-α均异常表达，且TNF-α受更多因素影响。ADP和TNF-α浓度影响妊娠结局。提示ADP和TNF-α可作为预测妊娠结局、判断患者病情及治疗的指标。
