Vrinceanu Daniela, Dumitru Mihai, Stefan Adrian, Neagos Adriana, Musat Gabriela, Nica Elena Adriana
ENT Department, Bucharest Emergency University Hospital, 010271 Bucharest, Romania.
Department of Anatomy, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Exp Ther Med. 2020 Sep;20(3):2377-2380. doi: 10.3892/etm.2020.8894. Epub 2020 Jun 17.
A case is presented of a male with drug rash with eosinophilia and systemic symptoms (DRESS) syndrome induced by carbamazepine intake. The patient presented all the elements of DRESS syndrome: Skin reaction, fever, enlargement of the lymph nodes, increased eosinophils and lymphocytes, with associated organ dysfunctions. The patient was admitted with acute laryngeal edema and imminence of respiratory insufficiency. The escalation of symptoms for this syndrome is typical, even after the administering of the the culprit medicine has ceased. However, in this case, the most difficult aspect was the complex treatment scheme prior to admission. All medical compounds involved in the background treatment were substituted with other substances in order to control the immune response. Current knowledge regarding DRESS is reviewed and possible influence of various etiologies over the present case are discussed. Clinicians should be aware of this rare situation with life-threatening potential. We benefited from the advantage of reuniting the knowledge of a complex team of experts from various tertiary emergency units in Romania.
本文介绍了一例因服用卡马西平诱发药物性皮疹伴嗜酸性粒细胞增多和全身症状（DRESS）综合征的男性病例。该患者具备DRESS综合征的所有要素：皮肤反应、发热、淋巴结肿大、嗜酸性粒细胞和淋巴细胞增多，并伴有相关器官功能障碍。患者因急性喉水肿和呼吸功能不全的紧迫情况入院。即使停用了致病药物，该综合征的症状仍会典型性地加重。然而，在本病例中，最困难的方面是入院前的复杂治疗方案。为了控制免疫反应，将背景治疗中涉及的所有药物换成了其他药物。本文回顾了关于DRESS的现有知识，并讨论了各种病因对本病例可能产生的影响。临床医生应意识到这种具有潜在生命威胁的罕见情况。我们受益于罗马尼亚各三级急诊单位的复杂专家团队所积累知识的优势。
