Marcu Dragos Radu, Iorga Lucian, Diaconu Camelia Cristina, Spinu Arsenie Dan, Mischianu Dan, Bratu Ovidiu Gabriel
Urology Clinic, 'Carol Davila' Central Military University Emergency Hospital, 010825 Bucharest, Romania.
Clinical Department 3, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Exp Ther Med. 2020 Sep;20(3):2406-2410. doi: 10.3892/etm.2020.8934. Epub 2020 Jun 24.
Radical prostatectomy is one of the most frequent therapeutic options used for the management of patients diagnosed with prostate cancer. Normal erectile function after radical prostatectomy is a great problem for numerous patients and a real challenge for urologists worldwide. The advancements that have been made over the years in terms of minimally invasive surgery, as well as in terms of surgical techniques, have reduced the incidence of erectile dysfunction, but even so, its rate remains high and the post-operative recovery of erectile function is a long and costly process. Phosphodiesterase 5 inhibitors have provided excellent results and have become the first-line treatment for these patients, followed by intracavernous injections with alprostadil. Several studies have underlined the impact of phosphodiesterase 5 inhibitors in terms of preventing the fibrotic changes that are responsible for the irreversible erectile dysfunction. The general opinion is that an erectile function recovery process should be started as soon as possible after surgery to prevent the negative effects of neuropraxia.
根治性前列腺切除术是用于治疗前列腺癌患者最常用的治疗选择之一。根治性前列腺切除术后的正常勃起功能对众多患者来说是一个大问题，对全球泌尿外科医生而言也是一项真正的挑战。多年来，在微创手术以及手术技术方面取得的进展降低了勃起功能障碍的发生率，但即便如此，其发生率仍然很高，而且勃起功能的术后恢复是一个漫长且成本高昂的过程。5型磷酸二酯酶抑制剂已取得了出色的效果，并成为这些患者的一线治疗方法，其次是海绵体内注射前列地尔。多项研究强调了5型磷酸二酯酶抑制剂在预防导致不可逆勃起功能障碍的纤维化改变方面的作用。普遍观点认为，术后应尽快启动勃起功能恢复进程，以预防神经失用的负面影响。
