Laboratory of Nutrition, Functional Food and Vascular Health, Department of Biochemistry, Faculty of Medicine, University of Monastir, Avenue Avicenne, 5019, Monastir, Tunisia.
Unit of Obesity and Metabolic Syndrome, Department of Endocrinology, University Hospital Hedi Chaker of Sfax, Sfax, Tunisia.
Lipids Health Dis. 2017 Dec 12;16(1):241. doi: 10.1186/s12944-017-0637-9.
Vasculogenic erectile dysfunction (VED) is considered as a common complication among people with type 2 diabetes (T2D). We tested whether changes in fatty acid (FAs) classes measured in erythrocytes are associated with increased risk of diabetic VED along with related risk factors.
We assessed erythrocyte FAs composition, lipid peroxidation parameters and inflammatory cytokines among 72 T2D men with VED, 78 T2D men without VED and 88 healthy volunteers with similar age. Biochemical, hepatic, lipid and hormonal profiles were measured.
T2D people with VED had significant decrease in the indexes of Δ6-desaturase and elongase activities compared to the other studied groups. The same group of participants displayed lower erythrocytes levels of dihomo-γ-linolenic acid (C20:3n-6) (P < .001), precursor of the messenger molecule PGE1 mainly involved in promoting erection. Moreover, absolute SFAs concentration and HOMA IR levels were higher in T2D people with VED when compared to controls and associated with impaired NO concentration (1.43 vs 3.30 ng/L, P < .001). Our results showed that IL-6 and TNF-α were significantly increased and positively correlated with MDA levels only in T2D people with VED (r = 0.884, P = .016 and r = 0.753, P = .035; respectively) suggesting a decrease in the relative availability of vasodilator mediators and an activation of vasoconstrictors release.
Our findings show that the deranged FAs metabolism represents a potential marker of VED in progress, or at least an indicator of increased risk within men with T2D.
血管性勃起功能障碍（VED）被认为是 2 型糖尿病（T2D）患者的常见并发症。我们检测了红细胞中脂肪酸（FAs）水平的变化是否与糖尿病性 VED 风险增加以及相关危险因素有关。
我们评估了 72 名 T2D 合并 VED 男性、78 名 T2D 不合并 VED 男性和 88 名年龄相似的健康志愿者的红细胞 FAs 组成、脂质过氧化参数和炎性细胞因子。检测了生化、肝脏、脂质和激素指标。
与其他研究组相比，T2D 合并 VED 患者的 Δ6-去饱和酶和延伸酶活性指数显著降低。同一组患者的红细胞二高-γ-亚麻酸（C20：3n-6）水平较低（P<0.001），C20：3n-6 是主要参与促进勃起的信使分子 PGE1 的前体。此外，与对照组相比，T2D 合并 VED 患者的绝对 SFAs 浓度和 HOMA-IR 水平更高，并且与 NO 浓度降低有关（1.43 与 3.30ng/L，P<0.001）。我们的结果表明，只有在 T2D 合并 VED 患者中，IL-6 和 TNF-α 显著增加，且与 MDA 水平呈正相关（r=0.884，P=0.016 和 r=0.753，P=0.035），提示血管扩张介质的相对可用性降低和血管收缩剂释放的激活。
我们的研究结果表明，FA 代谢紊乱可能是 VED 进展的潜在标志物，或者至少是 T2D 男性风险增加的指标。
