Langlois Fabienne, Suarez Gabriela M, Fleseriu Maria
Centre Hospitalier Universitaire de Sherbrooke, 3001 12e Avenue Nord, Sherbrooke, QC, J1H 5N4, Canada.
Pituitary Center, Departments of Medicine and Neurological Surgery, Oregon Health & Science University, 3303 South Bond Avenue, CH8N, Portland, OR, 97239, USA.
F1000Res. 2020 Jul 29;9. doi: 10.12688/f1000research.22683.1. eCollection 2020.
Acromegaly is a complex disease with excessive growth hormone and insulin-like growth factor 1 (IGF-1) causing multisystem effects, particularly cardiovascular, respiratory, and metabolic. Psychological concerns and poor quality of life (QoL) are also major disease consequences. This review is intended for clinicians and focuses on the latest developments related to respiratory and QoL effects of long-term growth hormone excess. Along with biochemical disease control, patient treatment satisfaction and outcomes have become major treatment objectives; current knowledge and tools to evaluate and manage this aspect of the disease are described. Sleep apnea syndrome and other derangements of lung function and apparatus, from pathophysiology to treatment, and evaluation tools and determinants of QoL in patients with acromegaly are discussed.
肢端肥大症是一种复杂的疾病，生长激素和胰岛素样生长因子1（IGF-1）分泌过多会导致多系统影响，尤其是心血管、呼吸和代谢系统。心理问题和生活质量（QoL）低下也是该疾病的主要后果。本综述面向临床医生，重点关注长期生长激素过多对呼吸和生活质量影响的最新进展。除了生化疾病控制外，患者治疗满意度和治疗结果已成为主要治疗目标；本文描述了评估和管理该疾病这一方面的现有知识和工具。讨论了睡眠呼吸暂停综合征以及肺功能和呼吸装置的其他紊乱情况，从病理生理学到治疗方法，还讨论了肢端肥大症患者的生活质量评估工具和决定因素。
