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Raltegravir-associated Drug-Reaction With Eosinophilia and Systemic Symptoms Syndrome in a Pediatric Patient Without Characteristic Human Leukocyte Antigen B*57:01 or B*53:01 alleles.拉替拉韦相关药物反应伴嗜酸性粒细胞增多和全身症状综合征在儿科患者中发生，该患者无特征性人类白细胞抗原 B*57:01 或 B*53:01 等位基因。
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2
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本文引用的文献

1
Drug reaction with eosinophilia and systemic symptoms related to antiretroviral treatment in human immunodeficiency virus patients.人类免疫缺陷病毒患者中与抗逆转录病毒治疗相关的伴有嗜酸性粒细胞增多和全身症状的药物反应。
Indian J Sex Transm Dis AIDS. 2017 Jul-Dec;38(2):163-170. doi: 10.4103/ijstd.IJSTD_70_17.
2
Dolutegravir as a trigger for DRESS syndrome?多替拉韦会引发药物超敏反应伴嗜酸性粒细胞增多和系统症状（DRESS）综合征吗？
Int J STD AIDS. 2018 Sep;29(10):1036-1038. doi: 10.1177/0956462418764973. Epub 2018 Apr 5.
3
Association of the HLA-B*53:01 Allele With Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome During Treatment of HIV Infection With Raltegravir.在使用拉替拉韦治疗HIV感染期间，HLA - B*53:01等位基因与药物超敏反应伴嗜酸性粒细胞增多和全身症状（DRESS）综合征的关联。
Clin Infect Dis. 2017 May 1;64(9):1198-1203. doi: 10.1093/cid/cix096.
4
Raltegravir-induced drug reaction with eosinophilia and systemic symptoms syndrome in a child.一名儿童出现的雷特格韦诱导的药物反应伴嗜酸性粒细胞增多和全身症状综合征。
Ann Allergy Asthma Immunol. 2016 Dec;117(6):719-721. doi: 10.1016/j.anai.2016.09.433. Epub 2016 Oct 27.
5
Drug Reaction with Eosinophilia and Systemic Symptoms in Children: A Prospective Study.儿童药物反应伴嗜酸性粒细胞增多和全身症状：一项前瞻性研究。
Pediatr Dermatol. 2016 Mar-Apr;33(2):e162-5. doi: 10.1111/pde.12803.
6
Dolutegravir: clinical and laboratory safety in integrase inhibitor-naive patients.多替拉韦：初治整合酶抑制剂患者的临床及实验室安全性
HIV Clin Trials. 2014 Sep-Oct;15(5):199-208. doi: 10.1310/hct1505-199.
7
DRESS syndrome: Part I. Clinical perspectives.药物反应伴嗜酸性粒细胞增多和全身性症状（DRESS）综合征：第一部分. 临床观点。
J Am Acad Dermatol. 2013 May;68(5):693.e1-14; quiz 706-8. doi: 10.1016/j.jaad.2013.01.033.
8
Association of human leukocyte antigen alleles and nevirapine hypersensitivity in a Malawian HIV-infected population.人类白细胞抗原等位基因与马拉维 HIV 感染人群中奈韦拉平过敏的关联。
Clin Infect Dis. 2013 May;56(9):1330-9. doi: 10.1093/cid/cit021. Epub 2013 Jan 29.
9
The DRESS syndrome: a literature review.药物反应伴嗜酸性粒细胞增多和全身性症状（DRESS）综合征：文献综述。
Am J Med. 2011 Jul;124(7):588-97. doi: 10.1016/j.amjmed.2011.01.017. Epub 2011 May 17.
10
Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms: does a DRESS syndrome really exist?伴有全身症状的药物皮肤副作用临床模式的变异性：药物超敏反应伴嗜酸性粒细胞增多和系统症状（DRESS）综合征真的存在吗？
Br J Dermatol. 2007 Mar;156(3):609-11. doi: 10.1111/j.1365-2133.2006.07704.x.

拉替拉韦相关药物反应伴嗜酸性粒细胞增多和全身症状综合征在儿科患者中发生，该患者无特征性人类白细胞抗原 B*57:01 或 B*53:01 等位基因。

Raltegravir-associated Drug-Reaction With Eosinophilia and Systemic Symptoms Syndrome in a Pediatric Patient Without Characteristic Human Leukocyte Antigen B*57:01 or B*53:01 alleles.

机构信息

Department of Pediatrics, Division of Infectious Diseases, Duke University School of Medicine, Durham, North Carolina, USA.

Duke Global Health Institute, Duke University School of Medicine, Durham, North Carolina, USA.

出版信息

J Pediatric Infect Dis Soc. 2021 Apr 3;10(3):363-366. doi: 10.1093/jpids/piaa089.

DOI:10.1093/jpids/piaa089
PMID:32766769
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8023309/
Abstract

We present the first published case of raltegravir-associated drug-reaction with eosinophilia and systemic symptoms (DRESS) syndrome in a child without characteristic human leukocyte antigen haplotypes HLA-B57:01 or HLA-B53:01. A 4-year-old African American female with perinatally acquired human immunodeficiency virus infection was hospitalized for DRESS after starting a raltegravir-based antiretroviral regimen.

摘要

我们报告了首例儿童 raltegravir 相关药物反应伴嗜酸性粒细胞增多和全身症状（DRESS）综合征病例，该患儿无特征性人类白细胞抗原单体型 HLA-B57:01 或 HLA-B53:01。一名 4 岁的非洲裔美国女性，出生时感染了人类免疫缺陷病毒，在开始 raltegravir 为基础的抗逆转录病毒治疗方案后因 DRESS 而住院。