Program on Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, CA, USA.
Arsenic Health Effects Research Program, School of Public Health, University of California, Berkeley, 2470 Telegraph Ave., Suite 301, Berkeley, CA, 94704, USA.
Curr Environ Health Rep. 2020 Sep;7(3):343-351. doi: 10.1007/s40572-020-00288-z.
Arsenic is associated with cancer, heart disease, diabetes, and other outcomes that are also related to obesity. These similar effects raise the possibility that arsenic plays a role in obesity causation. They also raise the possibility that obesity may be an important effect modifier of arsenic-caused disease. This review summarizes the complex relationship between arsenic and obesity, with an emphasis on current research from human studies.
Experimental studies provide some evidence that arsenic could play a role in obesity pathogenesis. To date, however, these associations have not been confirmed in human studies. In contrast, several epidemiologic studies have shown that the risks of arsenic-caused disease are markedly higher in obese individuals, highlighting obesity as an important susceptibility factor. Arsenic exposure and obesity are prevalent and widespread. Research identifying vulnerable populations, including obese individuals, could lead to new interventions having broad public health effects.
砷与癌症、心脏病、糖尿病和其他肥胖相关的结果有关。这些相似的影响增加了砷在肥胖症病因学中发挥作用的可能性。它们还增加了肥胖可能是砷引起的疾病的重要效应修饰因子的可能性。本综述总结了砷与肥胖之间的复杂关系，重点介绍了来自人类研究的最新研究结果。
实验研究提供了一些证据表明，砷可能在肥胖症发病机制中发挥作用。然而，迄今为止，这些关联在人类研究中尚未得到证实。相比之下，几项流行病学研究表明，肥胖个体患砷引起的疾病的风险明显更高，突出了肥胖作为一个重要的易感因素。砷暴露和肥胖普遍存在且广泛分布。识别易受影响人群（包括肥胖者）的研究可能会带来新的干预措施，从而对公众健康产生广泛影响。
