School of Clinical Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, China.
Mini Rev Med Chem. 2020;20(20):2153-2164. doi: 10.2174/1389557520666200807134921.
Traditional Chinese medicine (TCM) or herbs are widely used in the prevention and treatment of viral infectious diseases. However, the underlying mechanisms of TCMs remain largely obscure due to complicated material basis and multi-target therapeutics. TCMs have been reported to display anti-influenza activity associated with immunoregulatory mechanisms by enhancing host antiinfluenza immune responses. Previous studies have helped us understand the direct harm caused by the virus itself. In this review, we have tried to summarize recent progress in TCM-based anti-influenza research on the indirect harmful immune responses caused by influenza viruses. In particular, the phytochemicals from TCMs responsible for molecular mechanisms of action belonging to different classes, including phenolic compounds, flavonoids, alkaloids and polysaccharides, have been identified and demonstrated. In addition, this review focuses on the pharmacological mechanism, e.g., inflammatory responses and the interferon (IFN) signaling pathway, which can provide a theoretical basis and approaches for TCM based anti-influenza treatment.
传统中药（TCM）或草药在病毒性传染病的预防和治疗中被广泛应用。然而，由于复杂的物质基础和多靶点治疗，TCM 的潜在机制在很大程度上仍不清楚。TCM 被报道具有通过增强宿主抗流感免疫反应来显示与免疫调节机制相关的抗流感活性。先前的研究帮助我们了解了病毒本身直接造成的危害。在这篇综述中，我们试图总结基于 TCM 的抗流感研究的最新进展，即流感病毒引起的间接有害免疫反应。特别是，已经鉴定和证明了 TCM 中的植物化学物质具有属于不同类别的作用分子机制，包括酚类化合物、类黄酮、生物碱和多糖。此外，本综述还重点介绍了药理学机制，例如炎症反应和干扰素（IFN）信号通路，这可以为基于 TCM 的抗流感治疗提供理论基础和方法。
