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基于子宫电图的子宫收缩聚类分析

Uterine contractions clustering based on electrohysterography.

作者信息

Esgalhado Filipa, Batista Arnaldo G, Mouriño Helena, Russo Sara, Palma Dos Reis Catarina R, Serrano Fátima, Vassilenko Valentina, Ortigueira Manuel

机构信息

Laboratory of Instrumentation, Biomedical Engineering and Radiation Physics (LIBPhys-UNL), Department of Physics, NOVA School of Science and Technology, NOVA University Lisbon, 2829-516, Caparica, Portugal; NMT, S.A., Parque Tecnológico de Cantanhede, Núcleo 04, Lote 3, 3060 - 197, Cantanhede, Portugal.

NOVA School of Science and Technology - NOVA University Lisbon, 2829-516, Caparica, Portugal; UNINOVA, NOVA School of Science and Technology - NOVA University Lisbon, 2829-516, Caparica, Portugal.

出版信息

Comput Biol Med. 2020 Aug;123:103897. doi: 10.1016/j.compbiomed.2020.103897. Epub 2020 Jul 17.

Abstract

The uterine electromyogram, also named Electrohysterogram (EHG), is a non-invasive technique that has been used for pregnancy and labour monitoring as well as for research work on uterine physiology. This technique is well established in this field. There is however a vast unexplored potential in the EHG that is currently the subject of interdisciplinary research work involving different scientific fields such as medicine, engineering, physics and mathematics. In this paper, an unsupervised clustering method is applied to a previously obtained set of frequency spectral representations of the respective EHG signal contractions that were previously automatically detected and delineated. An innovative approach using the complete spectrum projection is described, rather than a set of relevant points. The feasibility of the method is established despite the concerns of possible computational burden incurred by the processing of the whole spectrum. Given the unsupervised nature of this classification, a validation procedure was performed whereas the obtained clusters were labelled through the correlation with the common knowledge about the most relevant uterine contraction types, as described in the literature. As a result of this study, a spectral description of the Alvarez contractions was obtained where it was possible to breakdown these important events in two different types according to their spectrum. Spectral estimates of Braxton-Hicks contractions were also obtained and associated to one of the clusters. This led to a full spectral characterization of these uterine events.

摘要

子宫肌电图,也称为子宫电图(EHG),是一种非侵入性技术,已用于妊娠和分娩监测以及子宫生理学的研究工作。该技术在这一领域已得到充分确立。然而,EHG仍有巨大的未被探索的潜力,目前它是涉及医学、工程、物理和数学等不同科学领域的跨学科研究工作的主题。在本文中,一种无监督聚类方法被应用于先前获得的一组各自的EHG信号收缩的频谱表示,这些收缩先前已被自动检测和描绘。本文描述了一种使用完整频谱投影的创新方法,而不是一组相关点。尽管处理整个频谱可能会带来计算负担,但该方法的可行性得到了确立。鉴于这种分类的无监督性质,进行了验证程序,通过与文献中描述的最相关子宫收缩类型的常识相关性对获得的聚类进行标记。作为这项研究的结果,获得了阿尔瓦雷斯收缩的频谱描述,根据其频谱可以将这些重要事件分为两种不同类型。还获得了布拉克斯顿-希克斯收缩的频谱估计,并将其与其中一个聚类相关联。这导致了对这些子宫事件的完整频谱特征描述。

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