Ministry of Health, Belfast, Antrim, Oman.
Reproductive and Developmental Biology Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK.
J Pain Symptom Manage. 2021 Jan;61(1):167-189.e14. doi: 10.1016/j.jpainsymman.2020.07.037. Epub 2020 Aug 5.
Fatigue is a particularly common and troubling symptom that has a negative impact on quality of life throughout all phases of treatment and stages of the illness among patients with cancer.
The objective of this meta-analysis is to examine the present status of fatigue prevalence in patients with cancer.
The following databases were searched: PubMed, MEDLINE, EMBASE, PsycINFO, Cochrane Library, from inception up to February 2020. Prevalence rates were pooled with meta-analysis using a random-effects model. Heterogeneity was tested using I-squared (I) statistics.
A total of 129 studies (N = 71,568) published between 1993 and 2020 met the inclusion criteria. The overall prevalence of fatigue was 49% (34,947 of 71,656 participants, 95% CI = 45-53) with significant heterogeneity between studies (P < 0.000; τ = 0.0000; I = 98.88%). Subgroup analyses show that the prevalence of fatigue related to type of cancer ranged from 26.2% in patients with gynecological cancer to 56.3% in studies that included mixed types of cancer. In advanced cancer stage patients, the highest prevalence of fatigue (60.6%) was reported. Fatigue prevalence rates were 62% during treatment and 51% during mixed treatment status. The prevalence of fatigue decreased from 64% in studies published from 1996 to 2000 to 43% in studies published from 2016 to 2020. Metaregression identified female gender as a significant moderator for higher prevalence of fatigue, whereas mean age is not associated with fatigue.
This meta-analysis highlights the importance of developing optimal monitoring strategies to reduce fatigue and improve the quality of life of patients with cancer.
疲劳是一种特别常见和令人困扰的症状，它会对癌症患者在治疗的各个阶段和疾病的各个阶段的生活质量产生负面影响。
本荟萃分析旨在检查癌症患者疲劳发生率的现状。
检索了以下数据库：PubMed、MEDLINE、EMBASE、PsycINFO、Cochrane 图书馆，从建立到 2020 年 2 月。使用随机效应模型对患病率进行荟萃分析。使用 I 平方（I）统计量检验异质性。
共有 129 项研究（N=71568）于 1993 年至 2020 年期间发表，符合纳入标准。疲劳的总体发生率为 49%（34947/71656 名参与者，95%CI=45-53），研究之间存在显著异质性（P<0.000；τ=0.0000；I=98.88%）。亚组分析表明，与癌症类型相关的疲劳发生率从妇科癌症患者的 26.2%到包括混合类型癌症的研究中的 56.3%不等。在晚期癌症患者中，疲劳的发生率最高（60.6%）。治疗期间的疲劳发生率为 62%，混合治疗状态下的疲劳发生率为 51%。1996 年至 2000 年发表的研究中疲劳发生率为 64%，2016 年至 2020 年发表的研究中疲劳发生率为 43%。元回归确定女性性别是疲劳发生率较高的重要调节因素，而平均年龄与疲劳无关。
本荟萃分析强调了制定最佳监测策略以减轻疲劳和提高癌症患者生活质量的重要性。
