University of Alabama at Birmingham School of Public Health, 1665 University Blvd, Birmingham, AL, 35211, USA.
Idaho State University, 921 S 8th Ave, Stop 8112, Pocatello, ID, 83209, USA.
Drug Alcohol Depend. 2020 Oct 1;215:108189. doi: 10.1016/j.drugalcdep.2020.108189. Epub 2020 Jul 23.
Although insomnia is highly prevalent in alcohol use disorders(AUD), its associations with the severity of alcohol use, pre-existing psychiatric comorbidities and psychosocial problems are understudied. The present study evaluates the interplay between these factors using a structural equation model (SEM).
We assessed baseline cross-sectional data on patients with AUD (N = 123) recruited to a placebo-controlled medication trial. Severity of alcohol use was measured by the Brief Michigan Alcoholism Screening Test (B-MAST). Insomnia Severity Index was used to assess insomnia symptoms. The Hamilton scales for Depression and Anxiety, Short Index of Problems and Timeline Follow Back evaluated psychiatric symptoms, psychosocial consequences of drinking and level of alcohol consumption respectively. We used logistic regression to evaluate the association between insomnia and severity of alcohol use while controlling for covariates. We constructed a SEM with observed variables to delineate the effect of psychiatric symptoms, psychosocial factors and current alcohol use on the pathway between alcohol use severity and insomnia.
The sample was predominately male(83.9 %), Black(54.6 %) and employed(60.0 %). About 45 % of the participants reported moderate-severe insomnia.The association between insomnia and B-MAST attenuated after adjustment for demographics, psychiatric symptoms and psychosocial problems(OR[95 % CI] = 1.17(0.99-1.47). SEM findings demonstrated that B-MAST and insomnia were linked to psychiatric symptoms (95 % Asymptotic-Confidence Interval (ACI): 0.015-0.159, p < 0.05) but not to psychosocial problems or current alcohol use.
Among treatment-seeking patients with AUD, psychiatric burden mediated the relationship between severity of alcohol use and insomnia. Clinicians should screen for underlying psychiatric disorders among treatment-seeking patients with AUD complaining of insomnia.
尽管失眠在酒精使用障碍(AUD)中非常普遍,但它与酒精使用的严重程度、先前存在的精神共病和心理社会问题之间的关系尚未得到充分研究。本研究使用结构方程模型(SEM)评估这些因素之间的相互作用。
我们评估了招募参加安慰剂对照药物试验的 AUD 患者(N=123)的基线横断面数据。酒精使用的严重程度通过简短密歇根酒精筛查测试(B-MAST)来衡量。使用失眠严重程度指数评估失眠症状。汉密尔顿抑郁和焦虑量表、简短问题索引和时间线随访回溯分别评估精神症状、饮酒的心理社会后果和酒精摄入量。我们使用逻辑回归评估失眠与酒精使用严重程度之间的关联,同时控制协变量。我们构建了一个包含观测变量的 SEM,以描绘精神症状、心理社会因素和当前酒精使用对酒精使用严重程度和失眠之间路径的影响。
该样本主要为男性(83.9%)、黑人(54.6%)和有工作(60.0%)。约 45%的参与者报告有中度至重度失眠。调整人口统计学、精神症状和心理社会问题后,失眠与 B-MAST 的关联减弱(OR[95%CI]=1.17(0.99-1.47))。SEM 结果表明,B-MAST 和失眠与精神症状相关(95%渐近置信区间(ACI):0.015-0.159,p<0.05),但与心理社会问题或当前酒精使用无关。
在寻求治疗的 AUD 患者中,精神负担介导了酒精使用严重程度与失眠之间的关系。临床医生应在因失眠而寻求治疗的 AUD 患者中筛查潜在的精神障碍。