Seeing is believing: Visualizing immune cells and calcium signals at different stages of neuroinflammation.
作者信息
Wang Liwei, Feske Stefan
机构信息
Department of Pathology, New York University School of Medicine, New York, NY 10016.
Department of Pathology, New York University School of Medicine, New York, NY 10016
出版信息
Proc Natl Acad Sci U S A. 2020 Aug 25;117(34):20360-20362. doi: 10.1073/pnas.2013377117. Epub 2020 Aug 7.
Abstract
摘要
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本文引用的文献
1
Regulatory T cells suppress Th17 cell Ca signaling in the spinal cord during murine autoimmune neuroinflammation.调节性 T 细胞在小鼠自身免疫性神经炎症期间抑制脊髓中 Th17 细胞的 Ca 信号传导。
Proc Natl Acad Sci U S A. 2020 Aug 18;117(33):20088-20099. doi: 10.1073/pnas.2006895117. Epub 2020 Jul 30.
2
Tissue resident and follicular Treg cell differentiation is regulated by CRAC channels.组织驻留和滤泡 Treg 细胞分化受 CRAC 通道调节。
Nat Commun. 2019 Mar 12;10(1):1183. doi: 10.1038/s41467-019-08959-8.
3
Multiple sclerosis.多发性硬化症。
Nat Rev Dis Primers. 2018 Nov 8;4(1):43. doi: 10.1038/s41572-018-0041-4.
4
T-cell calcium dynamics visualized in a ratiometric tdTomato-GCaMP6f transgenic reporter mouse.在一个比率型 tdTomato-GCaMP6f 转基因报告小鼠中可视化 T 细胞钙离子动力学。
Elife. 2017 Dec 14;6:e32417. doi: 10.7554/eLife.32417.
5
Visualizing context-dependent calcium signaling in encephalitogenic T cells in vivo by two-photon microscopy.通过双光子显微镜在体可视化致脑炎 T 细胞中依赖于上下文的钙信号。
Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):E6381-E6389. doi: 10.1073/pnas.1701806114. Epub 2017 Jul 17.
6
Regulatory T cells in multiple sclerosis and myasthenia gravis.多发性硬化症和重症肌无力中的调节性T细胞。
J Neuroinflammation. 2017 Jun 9;14(1):117. doi: 10.1186/s12974-017-0892-8.
7
Selective ORAI1 Inhibition Ameliorates Autoimmune Central Nervous System Inflammation by Suppressing Effector but Not Regulatory T Cell Function.选择性抑制ORAI1通过抑制效应性T细胞而非调节性T细胞功能改善自身免疫性中枢神经系统炎症。
J Immunol. 2016 Jan 15;196(2):573-85. doi: 10.4049/jimmunol.1501406. Epub 2015 Dec 16.
8
Treg cells mediate recovery from EAE by controlling effector T cell proliferation and motility in the CNS.调节性 T 细胞通过控制中枢神经系统中效应 T 细胞的增殖和迁移来介导 EAE 的恢复。
Acta Neuropathol Commun. 2014 Dec 5;2:163. doi: 10.1186/s40478-014-0163-1.
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Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation.Orai1 通过钙信号传导对于驱动 Th17 分化的核孤儿受体途径的诱导是必不可少的。
J Immunol. 2014 Jan 1;192(1):110-22. doi: 10.4049/jimmunol.1302586. Epub 2013 Dec 4.
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