Nath Sonia, Prakash Jayant, Prajapati Virendra Kumar, Sharma Nitesh, Pulikkotil Shaju Jacob
Department of Dentistry, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India.
Senior Lecturer, Hazaribagh College of Dental Sciences and Hospital, Hazaribagh, Jharkhand, India.
Indian J Dent Res. 2020 May-Jun;31(3):433-438. doi: 10.4103/ijdr.IJDR_783_17.
Bidi, a leaf rolled cigarette, is the most popular form of smoking in India. Bidi cigarette contains higher tar, ammonia, and nicotine content than a conventional cigarette and is more hazardous.
The aim of this study was to determine the effect of bidi smoking on periodontitis by assessing the interleukin (IL)-1β and IL-8 from a gingival crevicular fluid (GCF).
A total of 60 patients were selected, which included 40 patients diagnosed with chronic periodontitis (20 bidi smokers and 20 non-bidi smokers) and 20 periodontal healthy controls. Diseased and healthy sites were selected from each of the chronic periodontitis subjects. Clinical parameters assessed were plaque index (PI), gingival index (GI), periodontal probing depth (PPD), recession (RC), and clinical attachment level (CAL). Pooled GCF samples were taken from the same site and analyzed for IL-1β and IL-8 using enzyme-linked immunosorbent assay.
Bidi smokers displayed decreased levels of IL-1β and IL-8 than non-bidi smokers for both healthy and diseased sites and significantly reduced IL-8 levels among bidi smokers when compared to controls. Among bidi smokers, the diseased site had significantly higher levels of IL-8 than the healthy site. Non-smoker subjects with chronic periodontitis especially diseased sites contained significantly higher amounts of IL-1β and IL-8 than smokers and controls. The PI scores were highest among bidi smokers with reduced BOP and GI scores.
Bidi smoking influenced the cytokine profile among periodontitis patients exhibiting decreased levels of IL-1β and IL-8.
比迪烟，一种用叶子卷制的香烟，是印度最流行的吸烟形式。比迪烟所含的焦油、氨和尼古丁含量高于传统香烟，危害更大。
本研究的目的是通过评估龈沟液（GCF）中的白细胞介素（IL）-1β和IL-8来确定吸比迪烟对牙周炎的影响。
共选取60例患者，其中包括40例被诊断为慢性牙周炎的患者（20例吸比迪烟者和20例不吸比迪烟者）以及20例牙周健康对照者。从每位慢性牙周炎患者中选取患病部位和健康部位。评估的临床参数有菌斑指数（PI）、牙龈指数（GI）、牙周探诊深度（PPD）、牙龈退缩（RC）和临床附着水平（CAL）。从同一部位采集混合的龈沟液样本，并用酶联免疫吸附测定法分析IL-1β和IL-8。
对于健康部位和患病部位，吸比迪烟者的IL-1β和IL-8水平均低于不吸比迪烟者，且与对照组相比，吸比迪烟者的IL-8水平显著降低。在吸比迪烟者中，患病部位的IL-8水平显著高于健康部位。患有慢性牙周炎的非吸烟者，尤其是患病部位，其IL-1β和IL-8含量显著高于吸烟者和对照组。吸比迪烟者的PI评分最高，探诊出血（BOP）和GI评分降低。
吸比迪烟影响了牙周炎患者的细胞因子谱，表现为IL-1β和IL-8水平降低。
