作为药物洗脱剂的羟基磷灰石载体——一项分析。
Hydroxyapatite carriers as drug eluting agents-An analysis.
作者信息
Simon Deepti, Kumar K Ajith, Sivadasan Suresh Babu, Varma Harikrishna, Balan Anita
机构信息
Department of Oral & Maxillofacial Surgery, Government Dental College, Thiruvananthapuram, Kerala, India.
Bioceramics Laborotary, SCTIMST, Thiruvananthapuram, Kerala, India.
出版信息
Indian J Dent Res. 2020 May-Jun;31(3):481-485. doi: 10.4103/ijdr.IJDR_357_19.
INTRODUCTION
Hydroxyapatite based drug carriers offer a customized alternative to the delivery of pharmacologic agents in the osseous skeleton. They have an added advantage of being biocompatible and osteoconductive. This in vitro study aims to quantify the drug eluting properties of HA granules by spectrophotometry.
MATERIALS AND METHODS
HA and HASi beads were loaded with gentamicin/ amoxycillin- clavulanate/ vancomycin and grouped into 5. Drug elution was evaluated by means of UV spectrophotometry.
RESULTS
Drug eluent levels were well above bactericidal levels in all 5 groups.
CONCLUSION
HA and HASi are viable options for clinicians for targeted drug delivery.
引言
基于羟基磷灰石的药物载体为在骨骼中递送药物制剂提供了一种定制化的替代方案。它们具有生物相容性和骨传导性的额外优势。本体外研究旨在通过分光光度法量化羟基磷灰石颗粒的药物洗脱特性。
材料与方法
将庆大霉素/阿莫西林-克拉维酸/万古霉素负载到羟基磷灰石和含硅羟基磷灰石珠粒上，并分为5组。通过紫外分光光度法评估药物洗脱情况。
结果
所有5组的药物洗脱液水平均远高于杀菌水平。
结论
羟基磷灰石和含硅羟基磷灰石是临床医生进行靶向药物递送的可行选择。
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