Department of Pathology, Health Sciences University, Antalya Education and Research Hospital, Antalya, Turkey.
Department of Gynecologic Oncology, Health Sciences University, Antalya Education and Research Hospital, Antalya, Turkey.
Indian J Pathol Microbiol. 2020 Jul-Sep;63(3):412-417. doi: 10.4103/IJPM.IJPM_589_19.
Cyclin D1, a member of the cyclin protein family, is instrumental in the cell cycle due to its influence on the progression from G1 to the S phase. Its overexpression causes reduced doubling time and is also associated with clonogenic growth. The purpose of the present study was to assess cyclin D1 expression in patients with simple hyperplasia (SH), endometrial intraepithelial neoplasia (EIN) and endometrioid endometrial carcinoma, and to evaluate whether there was an association between cyclin D1 expression and the clinicopathological features of endometrioid endometrial carcinoma.
Retrospective data were available for 193 patients (30 SH, 40 EIN, and 123 endometrioid endometrial carcinoma cases). To detect cyclin D1 expression, immunohistochemistry staining was performed with tissue microarrays.
The percentage of cases with positive cyclin D1 staining were 30%, 60% and 78%, for SH, EIN and endometrioid endometrial carcinoma, respectively (P < 0.001). Carcinomas with higher nuclear grade, histological grade, and FIGO grade displayed higher mean cyclin D1 expression compared to lower grade carcinomas. In addition, patients with lymphovascular invasion (P = 0.006), myometrial invasion (P < 0.001) and lymph node invasion (P < 0.001) had higher mean cyclin D1 expression compared to those without invasion. There was a significant correlation between cyclin D1 expression and clinicopathological features of endometrioid endometrial carcinoma including tumor grade, FIGO grade, lymphovascular invasion, lymph node invasion and myometrial invasion (P < 0.05 for each).
Cyclin D1 expression is significantly higher in patients with endometrioid endometrial carcinoma compared to that of the SH and EIN. The extent of cyclin D1 expression is strongly correlated with nuclear and histological grade, myometrial invasion, lymphovascular invasion and lymph node invasion in patients with endometrioid endometrial carcinoma. These findings contribute in several ways to our understanding of cyclin D1 expression and provide a basis for future research on this topic.
细胞周期蛋白 D1 是细胞周期蛋白家族的成员，它通过影响 G1 期到 S 期的进展，在细胞周期中起着重要作用。其过度表达会导致倍增时间缩短，并且与克隆生长有关。本研究旨在评估单纯性增生症（SH）、子宫内膜上皮内瘤变（EIN）和子宫内膜样腺癌患者中 cyclin D1 的表达，并评估 cyclin D1 表达与子宫内膜样腺癌临床病理特征之间是否存在关联。
回顾性分析了 193 例患者（30 例 SH、40 例 EIN 和 123 例子宫内膜样腺癌）的临床资料。采用组织微阵列免疫组织化学染色法检测 cyclin D1 的表达。
SH、EIN 和子宫内膜样腺癌中 cyclin D1 染色阳性的病例百分比分别为 30%、60%和 78%（P<0.001）。核分级、组织学分级和 FIGO 分级较高的癌组织中 cyclin D1 的表达均值较高，而分级较低的癌组织中 cyclin D1 的表达均值较低。此外，有淋巴血管侵犯（P=0.006）、肌层浸润（P<0.001）和淋巴结侵犯（P<0.001）的患者 cyclin D1 的表达均值较高，而无侵犯的患者 cyclin D1 的表达均值较低。cyclin D1 的表达与子宫内膜样腺癌的临床病理特征（肿瘤分级、FIGO 分级、淋巴血管侵犯、淋巴结侵犯和肌层浸润）之间存在显著相关性（P<0.05）。
与 SH 和 EIN 相比，子宫内膜样腺癌患者 cyclin D1 的表达显著升高。cyclin D1 的表达程度与子宫内膜样腺癌患者的核和组织学分级、肌层浸润、淋巴血管侵犯和淋巴结侵犯密切相关。这些发现从多个方面加深了我们对 cyclin D1 表达的理解，为该主题的进一步研究提供了基础。
