Department of Pathology, Faculty of Medicine, Sıtkı Kocman University, Muğla, Turkey.
Indian J Pathol Microbiol. 2020 Jul-Sep;63(3):418-422. doi: 10.4103/IJPM.IJPM_783_19.
Endometrioid-type endometrial carcinoma is the most common malignancy of the female genital tract in developed countries. The prognosis greatly depends on the grade and stage of the disease.
In some patients, the disease recurs in a short time after the surgical/medical therapy. Hence, it is important to predict the patients who will have worse prognosis at the beginning, to choose the appropriate treatment; resuming the search of new prognostic markers. Therefore, our study aimed to detect trophoblast cell surface antigen 2 (TROP2) as a new prognostic marker.
The patients who underwent a hysterectomy and diagnosed with endometrioid-type endometrial carcinoma were evaluated retrospectively and TROP2 immunostain was performed to their tumoral slides.
We evaluated TROP2 expressions in 102 patients immunohistochemically who underwent hysterectomy with the diagnosis of endometrioid-type endometrial carcinoma histopathologically and correlated them with the other generally accepted prognostic parameters.
The Kolmogorov-Smirnov test and Q-Q plot test were used to verify the normality of the distribution of continuous variables. The Chi-square/Fisher's exact tests were used for categorical variables. Analyses were performed with SPSS Statistics for Windows, Version 20.
High overexpression of TROP2 was seen in larger, higher-grade, deeper-invasive tumors, tumors with vascular invasion, and pelvic-lymph-node metastasis. These results were statistically significant (P ≤ 0.05).
Overexpression of TROP2 in endometrioid-type endometrial carcinoma seems to be a poor prognostic factor; it may be useful in determining the biologically more aggressive tumors before the treatment. This early determination is very important to choose the appropriate surgery, adjuvant-treatments, and follow-up.
在发达国家，子宫内膜样型子宫内膜癌是女性生殖道最常见的恶性肿瘤。预后很大程度上取决于疾病的分级和分期。
在一些患者中，疾病在手术/药物治疗后短时间内复发。因此，重要的是要在一开始就预测出预后较差的患者，选择合适的治疗方法；重新寻找新的预后标志物。因此，我们的研究旨在检测滋养细胞表面抗原 2（TROP2）作为一种新的预后标志物。
回顾性评估了接受子宫切除术并诊断为子宫内膜样型子宫内膜癌的患者，并对其肿瘤切片进行了 TROP2 免疫染色。
我们用免疫组织化学方法评估了 102 例接受子宫切除术且病理诊断为子宫内膜样型子宫内膜癌的患者的 TROP2 表达，并将其与其他公认的预后参数相关联。
使用 Kolmogorov-Smirnov 检验和 Q-Q 图检验来验证连续变量分布的正态性。使用卡方/Fisher 确切检验来检验分类变量。使用 SPSS Statistics for Windows，Version 20 进行分析。
在较大、分级较高、侵袭较深、有血管侵犯和盆腔淋巴结转移的肿瘤中，TROP2 过表达较高。这些结果具有统计学意义（P≤0.05）。
子宫内膜样型子宫内膜癌中 TROP2 的过表达似乎是一个不良预后因素；它可能有助于在治疗前确定生物学上侵袭性更强的肿瘤。这种早期确定对于选择合适的手术、辅助治疗和随访非常重要。
