Division of Periodontics, Centre for Dental Education and Research, All India Institute of Medical Sciences, New Delhi, India.
Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.
Indian J Pathol Microbiol. 2020 Jul-Sep;63(3):441-444. doi: 10.4103/IJPM.IJPM_431_19.
Oral inflammatory myofibroblastic tumor (IMT) is extremely rare and its manifestation as generalized gingival enlargement (GGE) has never been reported. We are reporting the case of 50-year-old female patient presenting with recurrent GGE for 4 years. Panoramic radiograph revealed severe bone loss in posterior sextants and root resorption in some teeth. Initial incisional biopsy was suggestive of chronic inflammatory infiltrate with fibrocollagenous tissue. Definitive treatment comprised of surgical excision of the enlarged gingiva with a tapering dose of steroid therapy. Histopathological and immunohistochemical examination from a repeat biopsy of deeper tissues was suggestive IMT. No recurrence was found at 2 years follow up. Recurrent GGE with advanced bone loss and external root resorption should raise the suspicion of a locally aggressive lesion. Dentists should be aware of oral IMT and include it in differential diagnosis of gingival enlargements for comprehensive management to avoid recurrence of the lesion.
口腔炎性肌纤维母细胞瘤（IMT）极为罕见，其表现为广泛性牙龈肿大（GGE）从未有报道。我们报告了一例 50 岁女性患者，4 年来反复出现 GGE。全景片显示后六区严重骨丧失和一些牙齿的牙根吸收。初始切开活检提示为慢性炎症浸润伴纤维胶原组织。明确的治疗方法包括用逐渐减少剂量的类固醇治疗切除肿大的牙龈。来自深层组织重复活检的组织病理学和免疫组织化学检查提示为 IMT。2 年随访时未发现复发。复发性 GGE 伴有严重的骨丧失和外部牙根吸收，应引起对局部侵袭性病变的怀疑。牙医应意识到口腔 IMT，并将其纳入牙龈肿大的鉴别诊断中，以便进行全面管理，避免病变复发。
