Michael E. DeBakey Department of Surgery, Divisions of Pediatric Surgery and Surgical Research, Texas Children's Hospital Surgical Oncology Program, Dan L. Duncan Cancer Center.
Department of Pediatrics, Division of Hematology/Oncology, Texas Children's Cancer Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX.
J Pediatr Hematol Oncol. 2021 Jul 1;43(5):e685-e688. doi: 10.1097/MPH.0000000000001899.
Sclerosing encapsulating peritonitis (SEP) is a rare chronic inflammatory condition characterized by small bowel encapsulation by a thick fibrocollagenous membrane. Patients with SEP often present with nonspecific symptoms, such as abdominal pain and distension, however some patients may present with symptoms suggestive of intestinal obstruction. Secondary SEP has been reported in patients undergoing peritoneal dialysis and has been recently described in adults following cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC).
We report a clinical case of a 13-year-old female who presented with worsening abdominal pain and distension and persistent emesis who was found to have SEP 13 months following CRS and HIPEC for management of desmoplastic small round cell tumor and subsequently required operative intervention.
Although there have been published reports of adult patients experiencing cases of SEP following CRS/HIPEC, this is the first published case of secondary SEP occurring in a pediatric oncology patient.
硬化性包裹性腹膜炎（SEP）是一种罕见的慢性炎症性疾病，其特征是小肠被厚厚的纤维胶原膜包裹。SEP 患者常出现非特异性症状，如腹痛和腹胀，但有些患者可能出现肠梗阻的症状。腹膜透析患者发生继发性 SEP 已有报道，最近也有报道称在接受细胞减灭术和腹腔热灌注化疗（HIPEC）的成年人中发生。
我们报告了一例 13 岁女性患者的临床病例，该患者在接受细胞减灭术和 HIPEC 治疗促纤维增生性小圆细胞肿瘤 13 个月后出现腹痛和腹胀加重，并持续呕吐，被诊断为 SEP，随后需要手术干预。
尽管已有成人患者在接受细胞减灭术和 HIPEC 后发生 SEP 的报道，但这是首例发生在儿科肿瘤患者中的继发性 SEP 病例。
